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Endogenous glucocorticoids attenuate Shiga toxin-2-induced toxicity in a mouse model of haemolytic uraemic syndrome
(Wiley Blackwell Publishing, Inc, 2003-02)
The concept that during an immune challenge the release of glucocorticoids (GC) provides feedback inhibition on evolving immune responses has been drawn primarily from studies of autoimmune and/or inflammatory processes ...
Curating the gnomAD database: Report of novel variants in the thyrogobulin gene using in silico bioinformatics algorithms
(Elsevier Ireland, 2021-08)
Thyroglobulin (TG) is a large glycosylated protein of 2767 amino acids, secreted by the thyrocytes into the follicular lumen. It plays an essential role in the process of thyroid hormone synthesis. TG gene variants lead ...
Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17
(American Society of Investigative Pathology, 2012-09)
The pathogenic mechanisms of bone loss caused by Brucella species have not been completely deciphered. Although T lymphocytes (LTs) are considered important to control infection, the mechanism of Brucella-induced T-cell ...
Role of tryptophan residues in the toxicity and photosensitized inactivation of escherichia coli α-hemolysin
(American Chemical Society, 2020-10-27)
α-Hemolysin (HlyA) is an extracellular protein toxin secreted by uropathogenic strains of Escherichia coli that inserts into membranes of eukaryotic cells. The main goal of this work was to investigate the involvement of ...
Explorando el pasado reciente: servicios estadísticos de las Fuerzas Armadas Argentinas conexos a la Ley 17.622
(Universidad Nacional de Tres de Febrero. Centro de Estudios sobre Genocidio, 2017-11)
Mediante una extensa revisión de fuentes documentales, la investigación analiza el papel de la organización administrativa en torno a estadísticas militares y a sistemas conexos a datos poblacionales. Haciendo foco en un ...
Benznidazole-induced ultrastructural and biochemical alterations in rat colon
(Wiley Blackwell Publishing, Inc, 2000-11)
AIM: To study the effects of benznidazole (Bz), a drug used in the chemotherapy of the acute and the intermediate phase of Chagas' disease, on the colon of rats.
METHODS: Sprague Dawley male rats received Bz 100 mg/kg ig. ...
Cultivation of Pichia pastoris carrying the scFv anti LDL (−) antibody fragment. Effect of preculture carbon source
(Sociedade Brasileira de Microbiologia, 2017-07)
Antibodies and antibody fragments are nowadays among the most important biotechnological products, and Pichia pastoris is one of the most important vectors to produce them as well as other recombinant proteins. The conditions ...
Melatonin: Basic and clinical aspect
(Springer India, 2016)
Melatonin (MEL), the “hormone of darkness,” is an indolamine mainly secreted at night by the pineal gland. It is also synthesized by other tissues, being the enterochromaffin cells the most important extrapineal sites. The ...
Denatonium and Naringenin Promote SCA-9 Tumor Growth and Angiogenesis: Participation of Arginase
(Lawrence Erlbaum Assoc Inc-taylor & Francis, 2017-07)
Submandibular gland (SMG) is one of the major salivary glands, and is formed by acinar cells that are conveyed to the oral cavity by a duct system. We had previously reported that T2R receptors that were originally identified ...
Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
(Multidisciplinary Digital Publishing Institute, 2021-06)
The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic ...