Now showing items 41-50 of 5073
Flavonoids as GABAA receptor ligands: the whole story?
(Dove Medical Press, 2012-01)
Benzodiazepines are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side effects that they produce, such as sedation, myorelaxation, ataxia, amnesia, and ...
Phosphorylation of Ryanodine Receptors
(Sociedad de Biología de Chile, 2004)
Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein
(American Society for Biochemistry and Molecular Biology, 2004)
Accurate characterization of the molecular mechanisms of the action of ligands is an extremely important issue for their appropriate research, pharmacological, and therapeutic uses. In view of this fact, the aim of the ...
Ligand binding to CNS muscarinic receptor is transiently modified by convulsant 3-mercaptopropionic acid administration
(Springer/Plenum Publishers, 2000-06)
The administration of convulsant drugs has proven a powerful tool to study experimental epilepsy. We have already reported that the administration of convulsant 3-mercaptopropionic acid (mp) at 150 mg/kg enhances binding ...
Improved pan-specific prediction of MHC class I peptide binding using a novel receptor clustering data partitioning strategy
(Wiley Blackwell Publishing, Inc, 2016-12)
Pan-specific prediction of receptor–ligand interaction is conventionally done using machine-learning methods that integrates information about both receptor and ligand primary sequences. To achieve optimal performance using ...
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the ...
Allosteric positive interaction of thymol with the GABA-A receptor in primary cultures of mouse cortical neurons
(Pergamon-Elsevier Science Ltd, 2006-01)
Thymol is a naturally occurring phenolic monoterpene known for its anti-microbial and anti-oxidant properties. It is used in dental practice and in anaesthetic halothane preparations. Recent studies have reported enhanced ...
Identification of two surface proteins from C6/36 cells that bind dengue type 4 virus
(Journal of Virology, 1997-06-18)
Dengue viruses infect cells by attaching to a surface receptor, probably through the envelope (E) glycoprotein, located on the surface of the viral membrane. However, the identity of the dengue virus receptor in the mosquito ...
Differential effects of exercise on brain opioid receptor binding and activation in rats
Physical exercise stimulates the release of endogenous opioid peptides supposed to be responsible for changes in mood, anxiety, and performance. Exercise alters sensitivity to these effects that modify the efficacy at the ...