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Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet forms
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE FÍSICAUFMG, 2020)
Lipoplex functionalization with hyaluronic acid for safe and efficient delivery of siRNA to the retina
(Universidade Federal de Minas GeraisBrasilFARMACIA - FACULDADE DE FARMACIAPrograma de Pós-Graduação em Ciências FarmacêuticasUFMG, 2019-05-29)
Desde que o silenciamento de genes específicos relacionados a doenças na retina tornou-se uma realidade com o uso de pequenos RNAs interferentes (do inglês, small interfering RNAs – siRNAs), essa tecnologia tem sido ...
Inhibition of Junín virus replication by small interfering RNAs
(Elsevier Science, 2009-10)
Junín virus (JUNV), the etiological agent of the Argentine hemorrhagic fever, has a single-stranded RNA genome with ambisense expression which encodes for five proteins. In previous works we have demonstrated that the Z ...
Interferência por RNA: uma nova alternativa para terapia nas doenças reumáticas
(Sociedade Brasileira de Reumatologia, 2010-12-01)
RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. This mechanism, recently described, is mediated by small double-stranded RNAs (dsRNAs) that can specifically recognize ...
Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2007)
siARN y shARN: Aspectos básicos y aplicados : su uso como agentes terapéuticossiRNA and shRNA: basic and applied aspects : their use as therapeutic agentssiARN e shARN: aspectos básicos e aplicados : seu uso como agentes terapêuticos
(Federación Bioquímica de la Provincia Buenos Aires, 2011-12)
La interferencia del ARN es un fenómeno por el cual pequeñas moléculas de ARN doble cadena inhiben la expresión génica de manera secuencia específica. Esta vía se encuentra altamente conservada en los organismos eucariotas. ...
Silencing of HTLV-1 gag and env genes by small interfering RNAs in HEK 293 cells
(ELSEVIER SCIENCE BV, 2011)
Since the discovery of RNAi technology, several functional genomic and disease therapy studies have been conducted using this technique in the field of oncology and virology. RNAi-based antiviral therapies are being studied ...
Recent advances in siRNA delivery mediated by lipid-based nanoparticles
Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for
the treatment of broad-spectrum intractable diseases. However, its unfavorable properties
such as easy degradation in the blood and ...
Strand Analysis, a free online program for the computational identification of the best RNA interference (RNAi) targets based on Gibbs free energy
(Sociedade Brasileira de Genética, 2007-01-01)
The RNA interference (RNAi) technique is a recent technology that uses double-stranded RNA molecules to promote potent and specific gene silencing. The application of this technique to molecular biology has increased ...