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Mostrando ítems 151-160 de 268
Lipid-based transfection reagents can interfere with cholesterol biosynthesis
(Academic Press Inc Elsevier Science, 2016-02)
Lipid-based transfection reagents are widely used for delivery of small interfering RNA into cells. We examined whether the commonly used commercial transfection reagents DharmaFECT-4 and Lipofectamine 2000 can interfere ...
AMPK signaling pathway is rapidly activated by T3 and regulates the cardiomyocyte growth
(North Holland PublishingLimerick, 2013-08-25)
Previous studies have indicated that AMP-activated protein kinase (AMPK) plays a critical role in the control of cardiac hypertrophy mediated by different stimuli such as thyroid hormone (TH). Although the classical effects ...
Dynamin-2 regulates the late steps of exocytosis in adrenal chromaffin cells through a mechanism that involves actin polymerizatión
(2014)
Dynamin is a GTPase required for the vesicle pinching off from the plasma membrane during the late steps of endocytosis. Growing evidences suggest that dynamin also participates duringregulated exocytosis; however its ...
Dynamin-2 regulates the late steps of exocytosis in adrenal chromaffin cells through a mechanism that involves actin polymerizatión
(2014)
Dynamin is a GTPase required for the vesicle pinching off from the plasma membrane during the late steps of endocytosis. Growing evidences suggest that dynamin also participates duringregulated exocytosis; however its ...
Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?
(Elsevier B.V., 2020-07-01)
Chikungunya virus (CHIKV) is a mosquito-transmitted virus of special concern as it causes Chikungunya fever, characterized by an acute febrile illness, rash, and arthralgia that can progress to chronic and debilitating ...
PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes
(2018-01-01)
Progesterone receptor membrane component-1 (PGRMC1) is a highly conserved multifunctional protein that is found in numerous systems, including reproductive system. Interestingly, PGRMC1 is expressed at several intracellular ...
SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β1 and PDGF
(American Physiological Society, 2011-05)
Liver fibrosis is an active process that involves changes in cell-cell and cell-extracellular matrix (ECM) interaction. Secreted protein, acidic and rich in cysteine (SPARC) is an ECM protein with many biological functions ...
Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3 beta/mTOR signaling pathway
(DR DIETRICH STEINKOPFF VERLAG, 2009)
Several studies have implicated the renin angiotensin system in the cardiac hypertrophy induced by thyroid hormone. However, whether Angiotensin type 1 receptor (AT(1)R) is critically required to the development of ...
Silenciamento da expressão da enzima óxido nítrico sintase neuronal (nNOS) em linhagem de neuroblastoma via siRNAs sintéticos em dupla fita
(2016-07-03)
O óxido nítrico (NO) é formado pelas enzimas NO sintases e desempenha papel na patogênese da neurodegeneração. NO sintase neuronais são expressas em áreas cerebrais lesionadas e sua inibição reduz efeitos de agentes ...
The Clock Gene Rev-erb alpha Regulates Pancreatic beta-Cell Function: Modulation by Leptin and High-Fat Diet
(Endocrine SocChevy Chase, 2012)