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Catalytic activity of a novel serine/threonine protein phosphatase PP5 from Leishmania majorActivite´ catalytique d’une nouvelle phosphatase de prote´ine se´rine/thre´onine PP5 de Leishmania major
(Princeps Editions, 2014-06)
Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. Our knowledge of protein phosphatases (PPs) and their implication in signaling events is very limited. Here we report the ...
Active and passive mechanisms drive secretory granule biogenesis during differentiation of the intestinal parasite Giardia lamblia
(American Society for Biochemistry and Molecular Biology, 2006-06-30)
The parasitic protozoan Giardia lamblia undergoes important changes to survive outside the intestine of its host by differentiating into infective cysts. During encystation, three cyst wall proteins (CWPs) are specifically ...
All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae
(American Society for Cell Biology, 2008-07)
The transfer of lipid-linked oligosaccharide to asparagine residues of polypeptide chains is catalyzed by oligosaccharyltransferase (OTase). In most eukaryotes, OTase is a hetero-oligomeric complex composed of eight different ...
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?
(Elsevier Gmbh, 2014-07)
BACKGROUND: Chagas disease or American Trypanosomiasis is caused by the flagellated protozoan parasite Trypanosoma cruzi (T. cruzi) and is recognized by the WHO as one of the world's 17 neglected tropical diseases. Only ...
Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity
(Taylor & Francis, 2013-07)
Autophagy is a cell process that in normal conditions serves to recycle cytoplasmic components and aged or damaged organelles. The autophagic pathway has been implicated in many physiological and pathological situations, ...
Planktonic and physico–chemical dynamics of a markedly fluctuating backwater pond associated with a lowland river (Salado River, Buenos Aires, Argentina)
(Wiley, 2001-06)
An investigation was performed in a pond (San Miguel) directly associated with the Salado River (Pampean grasslands). The aim of the study was to analyze river interactions. Physical and chemical conditions and the plankton ...
Characterization of TcCYC6 from Trypanosoma cruzi, a gene with homology to mitotic cyclins
(Elsevier, 2015-12-17)
Trypanosoma cruzi, the etiologic agent of Chagas disease, is a protozoan parasite with a life cycle that alternates between replicative and non-replicative forms, but the components and mechanisms that regulate its cell ...
Parasitism and Physiological Trade-Offs in Stressed Capybaras
(Public Library of Science, 2013-07)
Parasites play a key role in regulating wildlife population dynamics, but their impact on the host appears to be contextdependent. Evidence indicates that a synergistic interaction between stress, host condition and ...
Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
(Public Library Of Science, 2014-05)
Background
The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug ...
Structure, mechanism, and dynamics of UDP-galactopyranose mutase
(Elsevier Inc, 2014-10)
The flavoenzyme UDP-galactopyranose mutase (UGM) is a key enzyme in galactofuranose biosynthesis. The enzyme catalyzes the 6-to-5 ring contraction of UDP-galactopyranose to UDP-galactofuranose. Galactofuranose is absent ...