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Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation
(Dove Medical Press Ltd, 2015-01-01)
In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release ...
Terapia Antiadesão Para Crise Vaso-Oclusiva Em Doença Falciforme: Revisão Sistemática
(Universidade Federal de São Paulo (UNIFESP), 2017-11-24)
Objective: To evaluate the efficacy and safety of anti-adhesion agents in the management of painful crises in patients with sickle cell disease. Methods: Systematic review and meta-analysis of randomized controlled trials ...
Immune response induced by conjunctival immunization with polymeric antigen BLSOmp31 using a thermoresponsive and mucoadhesive in situ gel as vaccine delivery system for prevention of ovine brucellosis
(Elsevier Science, 2016-10)
Control of ovine brucellosis with subcellular vaccines can solve some drawbacks associated with the use of Brucella melitensis Rev.1. Previous studies have demonstrated that the polymeric antigen BLSOmp31 administered by ...
Mucosal immunization with polymeric antigen BLSOmp31 using alternative delivery systems against Brucella ovis in rams
(Elsevier Science, 2019-03)
Subcellular vaccines against ovine contagious epididymitis due Brucella ovis can solve some shortcomings associated with the use of Brucella melitensis Rev 1. We have demonstrated that the parenteral immunization with ...
F127 poloxamer effect on cytotoxicity induction of tumour cell cultures treated with doxorubicin
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2019-11)
Introduction: Hepatocellular carcinoma is the most common liver malignancy and the third leading cause of cancer death worldwide. One crucial limitation in the pharmacotherapy for this tumour is its chemotherapy-resistant ...