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Electroencephalographic characterization of pentylenetetrazole kindling in rats and modulation of epileptiform discharges by nitric oxide
(Springer, 2014)
Epileptogenesis is a progressive process which
culminates with spontaneous, recurrent and unpredictable
epileptic seizures due to enhanced neuronal excitability.
Well-characterized animal models of this process are ...
THE EFFECT of CORTICOSTERONE in RATS SUBMITTED TO the ELEVATED PLUS-MAZE and TO PENTYLENETETRAZOL-INDUCED CONVULSIONS
(Elsevier B.V., 1994-12-01)
1. in order to examine the effects of corticosterone in the anxiety response, the effect of acute, subchronic and chronic corticosterone (CORT) administration were studied using two animal models to study using two animal ...
Subconvulsant doses of pentylenetetrazol uncover the epileptic phenotype of cultured synapsin-deficient Helix serotonergic neurons in the absence of excitatory and inhibitory inputs
(2016-09-06)
Synapsins are a family of presynaptic proteins related to several processes of synaptic functioning. A
variety of reports have linked mutations in synapsin genes with the development of epilepsy. Among
the proposed ...
Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats
(Associação Brasileira de Divulgação Científica, 2002-04-01)
Venlafaxine, an atypical antidepressant drug, has been used to treat several neurological disorders, presenting excellent efficacy and tolerability. Clinical seizures after venlafaxine treatment have occasionally been ...
Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures
(Elsevier B.V., 2015-03-01)
Objective: Homer1a is a protein that regulates metabotropic glutamate receptors involved in neural plasticity processes. Recently, we demonstrated that Homer1a mRNA is enhanced after pilocarpine-induced status epilepticus. ...
Subconvulsant doses of pentylenetetrazol uncover the epileptic phenotype of cultured synapsin-deficient Helix serotonergic neurons in the absence of excitatory and inhibitory inputs
(2016-09-06)
Synapsins are a family of presynaptic proteins related to several processes of synaptic functioning. A
variety of reports have linked mutations in synapsin genes with the development of epilepsy. Among
the proposed ...
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment
(Elsevier Science Bv, 2016)
The efficiency of most of the new antiepileptic drugs (AEDs) on clinical trials still falls short the success reported in pre-clinical studies, possibly because the validity of the animal models is insufficient to fully ...