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Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007)
Peroxisome proliferator-activated receptor gamma(PPAR gamma) has been proposed as a therapeutic target for neurodegenerative diseases because of its anti-inflammatory action in glial cells. However, PPAR gamma agonists ...
Initial studies on mechanism of action and cell death of active N-oxide-containing heterocycles in Trypanosoma cruzi epimastigotes in vitro
(Cambridge University Press, 2014)
Chagas disease, endemic in 21 countries across Latin America, kills more people in the region each year than any other
parasite-borne disease. Therapeutic options have problems ranging from toxicity, poor efficacy, drug ...
Upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells
(2007)
Reactive iron is an important prooxidant factor, whereas GSH is a crucial component of a long-term adaptive system that allows cells to function during extended periods of high oxidative stress. In this work, the adaptive ...
SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Objectives: Determination of the SET protein levels in head and neck squamous cell carcinoma (HNSCC) tissue samples and the SET role in cell survival and response to oxidative stress in HNSCC cell lineages. Materials and ...
Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism
(Bioscientifica Ltd, 2014-05-01)
Progesterone has been associated with the development of gestational diabetes (GD) due to the enhancement of insulin resistance. As b-cell apoptosis participates in type 1 and type 2 diabetes pathophysiology, we proposed ...
usnic acid activity on oxidative and nitrosatide stress of azole-resistant candida albicans biofilm
(Georg Thieme Verlag Kg, 2016-08)
AbstractSeveral studies report about that (+)-usnic acid (UA), a secondary metabolite produced by lichens, inhibits growth of different bacteria, and fungi; however, mechanism of its antimicrobial activity remained unknown.In ...
Functional alterations in macrophages after hypoxia selection
(Soc Experimental Biology MedicineMaywoodEUA, 2007)