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Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: Understanding the action of the inhibitor GC7 on a murine macrophage cell line
(2014-01-30)
Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative ...
Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus
(BioMed Central LTD, 2015-10-29)
Syngonanthus arthrotrichus and Syngonanthus bisulcatus, currently known for Comanthera aciphylla (Bong.) L.R.Parra & Giul. and Comanthera bisulcata (Koern.) L.R. Parra & Giul, popularly known in Brazil as sempre-vivas, are ...
Hypusine Modification of the Ribosome-binding Protein eIF5A, a Target for New Anti-Inflammatory Drugs: Understanding the Action of the Inhibitor GC7 on a Murine Macrophage Cell Line
(Bentham Science Publ Ltd, 2014-01-01)
Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative ...
Real-Time and Simultaneous Monitoring of NO, NO 2 , and N 2 O Using Substrate–Integrated Hollow Waveguides Coupled to a Compact Fourier Transform Infrared (FT-IR) Spectrometer
(2019-01-01)
Nitrogen-based fertilizers have been used in modern agricultural activities resulting in a relevant emission source of nitrogen gases into the atmosphere, mainly nitric oxide (NO), nitrogen dioxide (NO 2 ), and nitrous ...
Multidrug-resistant protein inhibitor and phosphodiesterase inhibitor potentiate the vasodilator effect induced by photobiomodulation in isolated aortic rings
(2022-03-01)
A previous work indicates that the red LASER (660 nm) induces vascular relaxation by nitric oxide (NO)–dependent mechanism. NO activates soluble guanylate cyclase (sGC) which produces cGMP, the main effector in the ...
Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats
(Elsevier B.V., 2004-06-25)
Male Holtzman rats weighting 200-250 g were anesthetized with zoletil 50 mg/Kg (tiletamine chloridrate 125,0 mg and zolazepan chloridrate 125,0 mg) into quadriceps muscle and submitted an electrolytic lesion of the lateral ...
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses
(Cambridge University Press, 2016)
In humans, obesity before and during pregnancy is associated with both fetal macrosomia and growth restriction, and long-term cardiovascular risk in the offspring. We aimed to determine whether overweighted pregnant guinea ...
Chilean Native Fruit Extracts Inhibit Inflammation Linked to the Pathogenic Interaction Between Adipocytes and Macrophages
(Mary Ann Liebert, 2015)
Obesity is characterized by an increase in the infiltration of monocytes into the adipose tissue, causing an inflammatory condition associated with, for example, the development of insulin resistance. Thus, anti-inflammatory-based ...
Nitrosative stress drives heart failure with preserved ejection fraction
(Nature Publishing Group, 2019)
Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies. Here we report that concomitant metabolic and hypertensive ...
Elevation of NO Increases Ca2+ Entry and Resting Ca2+ and Na+ Concentrations in Skeletal Muscle Cells
(Cell Press, 2015)
Protein S-nitrosylation is a reversible post-translational modification and can
have profound effects on protein function in skeletal muscle. S-nitrosylation
has been proposed to exert regulatory effects on ion channels ...