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G-quadruplexes as novel cis-elements controlling transcription during embryonic development
(Oxford University Press, 2016-05)
G-quadruplexes are dynamic structures folded in G-rich single-stranded DNA regions. These structures have been recognized as a potential nucleic acid based mechanism for regulating multiple cellular processes such as ...
Simultaneous pre-concentration procedure for the determination of cadmium and lead in drinking water employing sequential multi-element flame atomic absorption spectrometry
(2007)
In this paper is proposed a simultaneous pre-concentration procedure using cloud point extraction for the determination of cadmium and lead in drinking water employing sequential multi-element flame atomic absorption ...
Receptor-Dependent 4D-QSAR Analysis of Peptidemimetic Inhibitors of Trypanosoma cruzi Trypanothione Reductase with Receptor-Based Alignment
(2012)
Receptor-dependent four-dimensional quantitative structure–activity relationship (RD-4D-QSAR) studies were applied on a series of 21 peptides reversible inhibitors of Trypanosoma cruzi trypanothione reductase (TR) (Amino ...
Ghrelina e secretagogos do hormônio de crescimento (GHS): modulação da secreção do hormônio de crescimento e perspectivas terapêuticas
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-07-01)
Growth hormone-releasing hormone (GHRH) and somatostatin modulate growth hormone (GH) secretion. A third mechanism was discovered in the last decade, involving the action of growth hormone secretagogues (GHS). Ghrelin, the ...
Amplifying immunogenicity of prospective Covid-19 vaccines by glycoengin- eering the coronavirus glycan-shield to present α-gal epitopes
The many carbohydrate chains on Covid-19 coronavirus SARS-CoV-2 and its S-protein form a glycanshield that masks antigenic peptides and decreases uptake of inactivated virus or S-protein vaccines by APC.
Studies on ...
Computer-aided drug design against spike glycoprotein of SARS-CoV-2 to aid COVID-19 treatment
Background: SARS-CoV-2 has the Spike glycoprotein (S) which is crucial in attachment with host receptor and cell
entry leading to COVID-19 infection. The current study was conducted to explore drugs against Receptor ...
Macrophage apoptosis using alendronate in targeted nanoarchaeosomes
(Elsevier Science, 2021-03)
Nanoarchaeosomes are non-hydrolysable nanovesicles made of archaeolipids, naturally functionalised with ligand for scavenger receptor class 1. We hypothesized that nitrogenate bisphosphonate alendronate (ALN) loaded ...
A MarR-Type regulator directly activates transcription from the Brucella abortus virB promoter by sharing a redundant role with HutC
(American Society for Microbiology, 2012-09)
Type IV secretion systems (T4SS) are multiprotein structures that direct the translocation of specific molecules across the bacterial cell envelope. As in other bacteria, pathogenicity of the genus Brucella essentially ...
Dysregulation of Neuronal Nicotinic Acetylcholine Receptor-Cholesterol Crosstalk in Autism Spectrum Disorder
(Frontiers Media, 2021-10)
Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, ...
AKT
(Springer, 2018)
AKT is a serine/threonine kinase member of the AGC family of protein kinases. The three isoforms of AKT (AKT1/2/3) play a central role in growth, proliferation, glucose uptake, metabolism, protein translation and cell ...