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The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies
(Royal Soc Chemistry, 2021-04-23)
The conceptual technology of small molecule glycomimetics, exemplified by compounds C1-4, has shown promising protective effects against lipid-induced endothelial dysfunction, restorative effects on diabetic endothelial ...
One‐pot synthesis of anilides, herbicidal activity and molecular docking study
(Pest Management Science, 2018)
Characterization of a novel sugar transporter involved in sugarcane bagasse degradation in Trichoderma reesei
(BioMed Central, 2018)
Abstract
Background
Trichoderma reesei is a saprophytic fungus implicated in the degradation of polysaccharides present in the cell wall of plants. T. reesei has been ...
Homology model and docking-based virtual screening for ligands of human dyskerin as new inhibitors of telomerase for cancer treatment
(Molecular Diversity Preservation International, 2018-10)
Immortality is one of the main features of cancer cells. Tumor cells have an unlimited replicative potential, principally due to the holoenzyme telomerase. Telomerase is composed mainly by dyskerin (DKC1), a catalytic ...
Gold(III) heteroleptic complexes with SNS-thiosemicarbazonate ligands as cytotoxic agents: Experimental and computational insights into the mechanism of action
(2022-06-01)
New gold(III) heteroleptic complexes of general formula [AuX(dmtsc)], with (dmtsc)2– = (diethylaminothiocarbonyl)benzimidoyl-morpholinyl-thiosemicarbazonate and X = xant– (ethyl xanthate) or damp– (dimethyl-1-phenylmethanamine), ...
Aporphinoid Alkaloids Derivatives as Selective Cholinesterases Inhibitors: Biological Evaluation and Docking Study
(Wiley VCH Verlag, 2020-11)
Alzheimer's dementia is a neurodegenerative disease that affects the elderly population and causes memory impairment and cognitive deficit. Manifestation of this disease is associated to acetylcholine decrease; thus, ...
Aporphinoid Akaloids Derivatives as Selective Cholinesterases Inhibitors: Biological Evaluation and Docking Study
(Wiley-VCH Verlag GmbH & Co, 2020-02-11)
Alzheimer´s dementia is a neurodegenerative disease that affects the elderly population and causes memory impairment and cognitive deficit. Manifestation ofthis disease is associated to acetylcholine decrease; thus, ...