Buscar
Mostrando ítems 11-20 de 89
Exposure to BDE-153 induces autophagy in HepG2 cells
(2017-08-01)
Autophagy is a pro-survival process that occurs under stressful “life-threatening” conditions. This process clears the cells of damaged organelles, long-lived proteins, and/or misfolded proteins. Under stressful conditions, ...
Polycystin-1 regulates cardiomyocyte mitophagy
(Wiley, 2021)
Polycystin-1
(PC1) is a transmembrane protein found in different cell types, including
cardiomyocytes. Alterations in PC1 expression have been linked to mitochondrial
damage in renal tubule cells and in patients with ...
Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein
(Academic Press Inc Elsevier Science, 2018-04)
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the ...
Mitochondrial fission and autophagy in the normal and diseased heart
(2010)
Sustained hypertension promotes structural, functional and metabolic remodeling of cardiomyocyte mitochondria. As long-lived, postmitotic cells, cardiomyocytes turn over mitochondria continuously to compensate for changes ...
Novel insights into the pathogenesis of diabetic cardiomyopathy and pharmacological strategies
(Frontiers Media, 2021)
Diabetic cardiomyopathy (DCM) is a severe complication of diabetes developed mainly in
poorly controlled patients. In DCM, several clinical manifestations as well as cellular and
molecular mechanisms contribute to its ...
Contribution of Tau pathology to mitochondrial impairment in neurodegeneration
(Frontiers Media S.A., 2018)
Hallmarks of aging: An autophagic perspective
(Frontiers Media S.A., 2019-01)
Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress ...