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Simultaneous determination of melatonin and pyridoxine in tablets by gas chromatography-mass spectrometry
(PERGAMON-ELSEVIER SCIENCE, 2001-12)
A gas chroma tographic-mass spectrometric (GC-MS) method for the qualitative and quantitative determination of melatonin plus pyridoxine commercial tablets is described. Melatonin and pyridoxine were simultaneously determined ...
Melatonin therapy in patients with Alzheimer’s disease
(Multidisciplinary Digital Publishing Institute, 2014-04)
Alzheimer’s disease (AD) is a major health problem and a growing recognition exists that efforts to prevent it must be undertaken by both governmental and non-governmental organizations. In this context, the pineal product, ...
Oxidation of melatonin by AAPH-derived peroxyl radicals: Evidence of a pro-oxidant effect of melatonin
(Elsevier B.V., 2009-08-01)
Background: Melatonin is well-established as a powerful reducing agent of oxidant generated in the cell medium. We aimed to investigate how readily melatonin is oxidized by peroxyl radicals ROO(-) generated by the thermolysis ...
Oxidation of melatonin by AAPH-derived peroxyl radicals: Evidence of a pro-oxidant effect of melatonin
(Elsevier B.V., 2009-08-01)
Background: Melatonin is well-established as a powerful reducing agent of oxidant generated in the cell medium. We aimed to investigate how readily melatonin is oxidized by peroxyl radicals ROO(-) generated by the thermolysis ...
Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats
(American Physiological SocietyBethesda, 2013-07-15)
Melatonin can contribute to glucose homeostasis either by decreasing gluconeogenesis or by counteracting insulin resistance in distinct models of obesity. However, the precise mechanism through which melatonin controls ...
Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
(Sociedad Chilena de Anatomía, 2009)
Evaluation of melatonin effect on human breast cancer stem cells using a threedimensional growth method of mammospheres
(2017-01-01)
Background: The high rates of women's death from breast cancer occur due to acquired resistance by patients to certain treatments, enabling the recurrence and/or tumor growth, invasion and metastasis. It has been demonstrated ...
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial
(2018-11-01)
This work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); ...
Evaluation of melatonin and AFMK levels in women with breast cancer
(2018-10-01)
Purpose: Changes in the circadian rhythm may contribute to the development of cancer and are correlated with the high risk of breast cancer (BC) in night workers. Melatonin is a hormone synthesized by the pineal gland at ...