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Biased agonism at histamine H1 receptor: desensitization, internalization and MAPK activation triggered by antihistamines
(Elsevier Science, 2021-04)
Histamine H1 receptor ligands used clinically as antiallergics rank among the most widely prescribed and over-the-counter drugs in the world. They exert the therapeutic actions by blocking the effects of histamine, due to ...
Regulation of Multidrug Resistance-Associated Protein 2 by Calcium Signaling in Mouse Liver
(JOHN WILEY & SONS INC, 2010)
Mu hiding resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion secretion into bile. Mrp2 activity is regulated by insertion into the plasma membrane; however, the factors that ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015-08)
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs need to be ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015)
Abstract: The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs ...
Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism
(BioScientifica Ltd., 2014)
In the rat oviduct, estradiol (E2) accelerates egg transport by a nongenomic action that requires previous conversion of E2 to methoxyestrogens via catechol-O-methyltranferase (COMT) and activation of estrogen receptor ...
Modulação do influxo de cálcio pelo peptídeo YY (3-36) em células do hipocampo de ratos
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Peptide YY (PYY) belongs to the neuropeptide Y (NPY) family, which also includes the neuropeptide Y (NPY) and pancreatic polipeptide (PP). These substances are biologically active, constituted of 36 aminoacids, and act via ...
Modulação do influxo de cálcio pelo peptídeo YY (3-36) em células do hipocampo de ratos
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Peptide YY (PYY) belongs to the neuropeptide Y (NPY) family, which also includes the neuropeptide Y (NPY) and pancreatic polipeptide (PP). These substances are biologically active, constituted of 36 aminoacids, and act via ...
La interrupción de la comunicación vía Ca2+ entre el retículo endoplasmático y la mitocondria reduce la migración e invasión celular
(Universidad de Chile, 2015)
La mitocondria y el retículo endoplasmático (ER) se encuentran física y
funcionalmente acoplados. Los receptores de inositol 1,4,5-trifosfato (IP3R) son los
principales canales de Ca2+ responsables de la liberación de ...
Cálcio intracelular na proliferação de células hepáticas
(Universidade Federal de Minas GeraisUFMG, 2010-12-07)
Liver regeneration depends upon growth factors such as hepatic growth facto (HGF) and insulin that induce Ca2+ signals are necessary for proliferation of cells. Ca2+ signals in hepatocytes are mediated by inositol ...
IGF-1 Induces IP3-Dependent Calcium Signal Involved in the Regulation of Myostatin Gene Expression Mediated by NFAT During Myoblast Differentiation
(Wiley Periodicals, 2013)
Skeletal muscle differentiation is a complex and highly regulated process characterized by cell cycle arrest, which is associated with
morphological changes including myoblast alignment, elongation, and fusion into ...