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Biased agonism at histamine H1 receptor: desensitization, internalization and MAPK activation triggered by antihistamines
(Elsevier Science, 2021-04)
Histamine H1 receptor ligands used clinically as antiallergics rank among the most widely prescribed and over-the-counter drugs in the world. They exert the therapeutic actions by blocking the effects of histamine, due to ...
Regulation of Multidrug Resistance-Associated Protein 2 by Calcium Signaling in Mouse Liver
(JOHN WILEY & SONS INC, 2010)
Mu hiding resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion secretion into bile. Mrp2 activity is regulated by insertion into the plasma membrane; however, the factors that ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015-08)
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs need to be ...
Resistance to inhibitors of cholinesterase 3 (Ric-3) expression promotes selective protein associations with the human α7-nicotinic acetylcholine receptor interactome
(Public Library of Science, 2015)
Abstract: The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs ...
Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism
(BioScientifica Ltd., 2014)
In the rat oviduct, estradiol (E2) accelerates egg transport by a nongenomic action that requires previous conversion of E2 to methoxyestrogens via catechol-O-methyltranferase (COMT) and activation of estrogen receptor ...
Modulação do influxo de cálcio pelo peptídeo YY (3-36) em células do hipocampo de ratos
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Peptide YY (PYY) belongs to the neuropeptide Y (NPY) family, which also includes the neuropeptide Y (NPY) and pancreatic polipeptide (PP). These substances are biologically active, constituted of 36 aminoacids, and act via ...
Modulação do influxo de cálcio pelo peptídeo YY (3-36) em células do hipocampo de ratos
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Peptide YY (PYY) belongs to the neuropeptide Y (NPY) family, which also includes the neuropeptide Y (NPY) and pancreatic polipeptide (PP). These substances are biologically active, constituted of 36 aminoacids, and act via ...
IGF-1 Induces IP3-Dependent Calcium Signal Involved in the Regulation of Myostatin Gene Expression Mediated by NFAT During Myoblast Differentiation
(Wiley Periodicals, 2013)
Skeletal muscle differentiation is a complex and highly regulated process characterized by cell cycle arrest, which is associated with
morphological changes including myoblast alignment, elongation, and fusion into ...
La interrupción de la comunicación vía Ca2+ entre el retículo endoplasmático y la mitocondria reduce la migración e invasión celular
(Universidad de Chile, 2015)
La mitocondria y el retículo endoplasmático (ER) se encuentran física y
funcionalmente acoplados. Los receptores de inositol 1,4,5-trifosfato (IP3R) son los
principales canales de Ca2+ responsables de la liberación de ...
Cálcio intracelular na proliferação de células hepáticas
(Universidade Federal de Minas GeraisUFMG, 2010-12-07)
Liver regeneration depends upon growth factors such as hepatic growth facto (HGF) and insulin that induce Ca2+ signals are necessary for proliferation of cells. Ca2+ signals in hepatocytes are mediated by inositol ...