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Mostrando ítems 11-20 de 59
Efeito modulador da progesterona, vitamina D e silibinina sobre inflamassomas em monócitos de gestantes portadoras de pré-eclâmpsia
(Universidade Estadual Paulista (Unesp), 2019-02-28)
A pré-eclâmpsia (PE) é uma síndrome específica da gravidez, associada com inflamação sistêmica exacerbada, o que poderia ser dependente da deficiência de fatores reguladores, como a silibinina (SB), progesterona (PG) e ...
In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline: Involvement of caspase cascades and IκBα phosphorylation
(2006)
The aim of this work was to investigate whether in vivo and in vitro pentoxifylline (PTX) sensitizes hematological tumor cells to adriamycin (ADM)-induced apoptosis, and to investigate the involvement of caspase cascades ...
Regulation of cell survival by resveratrol involves inhibition of NFκB-regulated gene expression in prostate cancer cells
(2009)
BACKGROUND. Polyphenols have been proposed as antitumoral agents. We have shown that resveratrol (RES) induced cell cycle arrest and promoted apoptosis in prostate cancer cells by inhibition of the PI3K pathway. The RES ...
The NFkB pathway is down-regulated by 1α,25(OH)2-Vitamin D3 in endothelial cells transformed by Kaposi Sarcoma-associated herpes virus G protein coupled receptor
(Elsevier Science Inc, 2012-05)
We have previously demonstrated that 1α,25 dihydroxy-vitamin D3 (1α,25(OH)2D3) has antiproliferative effects on the growth of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma ...
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
(Nature Publishing Group, 2010-06)
Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in NF-κB signalling triggered by TNF-α1, 2. Genetic evidence indicates that TRAF2 is necessary for the polyubiquitination of receptor ...
Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog
(Karger, 2009-12)
Background: The major triterpene glycoside of the sea cucumber Psolus patagonicus and its desulfated analog were tested for their antiproliferative, cytotoxic and hemolytic activities, and their effect on NF-κB activation. ...
NF-κB inhibitors impair platelet activation responses
(Wiley Blackwell Publishing, Inc, 2009-12)
Background: Although platelets are anucleated cells, they express several transcription factors that exert non-genomic functions, including the positive and negative regulation of platelet activation. NF-κB is a major ...
Catabolic Signaling Pathways, Atrogenes, and Ubiquitinated Proteins Are Regulated by the Nutritional Status in the Muscle of the Fine Flounder
(Public Library of Science (PLoS), 2012-09)
A description of the intracellular mechanisms that modulate skeletal muscle atrophy in early vertebrates is still lacking. In this context, we used the fine flounder, a unique and intriguing fish model, which exhibits ...
Correction: Catabolic Signaling Pathways, Atrogenes, and Ubiquitinated Proteins Are Regulated by the Nutritional Status in the Muscle of the Fine Flounder
(Public Library of Science (PLoS), 2020-12)
A description of the intracellular mechanisms that modulate skeletal muscle atrophy in early vertebrates is still lacking. In this context, we used the fine flounder, a unique and intriguing fish model, which exhibits ...
Avaliação do mecanismo de ação do derivado tiazolidínico LPSF/GQ-02 sobre a resistência à insulina, esteatose hepática e aterosclerose
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Ciencias Biologicas, 2018)