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Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells
(Elsevier Ireland, 2021-06)
Parathyroid hormone-related peptide (PTHrP) exerts its effects on cells derived from colorectal cancer (CRC) and tumor microenvironment and is involved in processes requiring the epithelial-mesenchymal transition (EMT). ...
Avaliação do efeito biológico da pentraxina 3 em linhagens de células tumorais humanas
(Universidade Federal de Minas GeraisUFMG, 2014-02-27)
The pentraxin 3 is an acute phase glycoprotein expressed in a wide variety of cells and plays a myriad of roles in biological processes including female fertility, innate immunity and angiogenesis. PTX3 interacts selectively ...
Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line
(Ribeirão Preto, 2014)
DNA methylation is essential in X chromosome inactivation and genomic imprinting, maintaining repression of XIST in the active X chromosome and monoallelic repression of imprinted genes. Disruption of the DNA methyltransferase ...
Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines
(oncotarget, 2018-04)
Mutation-driven activation of KRAS is crucial to cancer development. The humangene yields four mRNA splicing isoforms, 4A and 4B being translated to protein. Theirdifferent properties and oncogenic potential have been ...
Efeito de células tumorais estressadas e seus exosomos sobre a ativação de células dendríticas in vitro
(Universidade Estadual Paulista (Unesp), 2020-02-07)
A autofagia é um processo catabólico utilizado por todas as células para a manutenção da homeostase sob estresse celular. Células tumorais podem sequestrar a maquinaria autofágica para evitar a morte celular. Células ...
RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
(BioMed Central, 2017-11)
Background: RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition ofapoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents.The ...
The curcumin analog CH-5 exerts anticancer effects in human osteosarcoma cells via modulation of transcription factors p53/Sp1
(2018-07-01)
Curcumin is a potential anticancer drug with poor bioavailability, which limits its clinical use as a therapeutic agent. The aim of this study was a preliminary evaluation of the curcumin analogue CH-5 as a cytotoxic agent ...
Implementación del ensayo MTT (bromuro de 3-(3,4 -dimetiltiazol-2-il)-2,5- difeniltetrazolio) en líneas celulares tumorales y determinación de la viabilidad celular de análogos de ácidos nucleico
(Universidad de los AndesQuímicaFacultad de CienciasDepartamento de Química, 2017)
Los ensayos de viabilidad celular y en general las aproximaciones in vitro son uno de las primeros pasos que se realiza para evaluar los efectos de moléculas que podrían postularse como nuevas drogas. Por lo tanto, factores ...
Estudo das alterações de proteoglicanos e glicosaminoglicanos em linhagens celulares de câncer colorretal humano
(Universidade Federal de São Paulo (UNIFESP), 2009-03-25)
Proteoglycans (PG) are complex macromolecules composed of linear polysaccharide chains, the glycosaminoglycans (GAGs), covalently attached to a core protein. These GAG chains contain sulphate groups at various positions, ...