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Atypical β-S haplotypes: classification and genetic modulation in patients with sickle cell anemia
(2019-03-01)
β-S globin haplotype (β S haplotype) characterization in sickle cell anemia (SCA) patients is important because it assists individualized treatment. However, the patient with atypical haplotypes do not present detailed ...
Functionality and opposite roles of two interleukin 4 haplotypes in immune cells
(2017-01-01)
Cytokines expression can be influenced by polymorphisms in their respective coding genes. We associated the CTI/TTD haplotype (Hap-1) and TCI/CCI haplotype (Hap-2) in the IL4 gene formed by the -590, +33 and variable number ...
Functional VEGF haplotypes affect the susceptibility to hypertension
(Nature Publishing GroupLondonInglaterra, 2013)
Sliding window haplotype approaches overcome single SNP analysis limitations in identifying genes for meat tenderness in Nelore cattle
(2019-01-14)
Background: Traditional single nucleotide polymorphism (SNP) genome-wide association analysis (GWAA) can be inefficient because single SNPs provide limited genetic information about genomic regions. On the other hand, using ...
Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort
(Elsevier, 2022)
Background: Large-scale Parkinson's disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed ...
Haplotypes of alpha-globin gene regulatory element in two Brazilian native populations
(Wiley-lissNew YorkEUA, 2003)
Functional haplotypes in interleukin 4 gene associated with periodontitis
(2017-01-01)
Chronic periodontitis (CP) is an infectious inflammatory disease that affects tooth-supporting structures and in which dental plaque bacteria, immune mechanisms and genetic predisposition play important roles. Interleukin ...
A Comprehensive Haplotype Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
(Elsevier, 2019)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a gain-of-function mutation in HTT. Suppression of mutant HTT has emerged as a leading therapeutic strategy for HD, with allele-selective approaches ...