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Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases
(NLM (Medline), 2019)
Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two cases with this condition; one with ...
Menstrual irregularity: a possible clinical marker of metabolic dysfunction in women with class III obesity
(Informa Healthcare, 2010-10-01)
Purpose. To evaluate whether menstrual irregularity in morbidly obese women is indicative of metabolic dysfunction.Patients and Methods. Fifty-seven women with morbid obesity were evaluated. They were divided into two ...
Puberty and ovarian function in girls with type 1 diabetes mellitus
(2009)
Insulin is well known for its effects on carbohydrate metabolism, but this hormone also plays an important role in regulating ovarian function. Granulosa, theca and stromal ovarian cells may be affected by insulin deficiency ...
Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
(Elsevier Inc., 2011)
Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein ...
Clinical review: Hyperandrogenism and polycystic ovary syndrome in women with type 1 diabetes mellitus
(Endocrine Society, 2007)
Context: At present, women with type 1 diabetes (DM1) are being treated with supraphysiological doses of exogenous insulin with the aim of providing a strict metabolic control, thereby avoiding the long-term complications ...
Prenatal testosterone exposure induces insulin resistance, uterine oxidative stress and pro-inflammatory status in rats
(Elsevier Ireland, 2020-01)
Prenatal androgen excess is considered one of the main causes of the development of polycystic ovary syndrome. In this study, we investigated the effect of prenatal hyperandrogenization (PH) on the physiology of the adult ...
Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis
(Cambridge University Press, 2019-02)
Fetal programming by androgen excess is hypothesized as one of the main factors contributing to the development of polycystic ovary syndrome (PCOS). PCOS is more than a reproductive disorder, as women with PCOS also show ...