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Aminoacetone, a putative endogenous source of methylglyoxal, causes oxidative stress and death to insulin-producing RINm5f cells
(AMER CHEMICAL SOC, 2008)
Aminoacetone (AA), triose phosphates, and acetone are putative endogenous sources of potentially cytotoxic and genotoxic methylglyoxal (MG), which has been reported to be augmented in the plasma of diabetic patients. In ...
Trypanosoma cruzi MSH2: Functional analyses on different parasite strains provide evidences for a role on the oxidative stress response
(ELSEVIER SCIENCE BV, 2011)
Components of the DNA mismatch repair (MMR) pathway are major players in processes known to generate genetic diversity, such as mutagenesis and DNA recombination. Trypanosoma cruzi, the protozoan parasite that causes Chagas ...
Oxidative stress and inflammatory response increase during coronary artery bypass grafting with extracorporeal circulationEstresse oxidativo e resposta inflamatória aumentam durante cirurgia de revascularização miocárdica com circulação extracorpórea
(Sociedade Brasileira de Cirurgia Cardiovascular, 2012)
INTRODUCTION: Thiobarbituric acid-reactive substance is a marker of oxidative stress and has cytotoxic and genotoxic actions. C- reactive protein is used to evaluate the acute phase of inflammatory response. OBJECTIVES: ...
Amphotericin B in poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) nanoparticles against paracoccidioidomycosis
(OXFORD UNIV PRESS, 2009)
The present study reports on the preparation and testing of a desoxycholate amphotericin B (D-AMB) sustained delivery system based on poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) polymeric blends ...
Dinâmica do arsênio no sistema solo - água - arroz na América do Sul: distinções fisiológicas entre cultivares e ocorrência em grãos comerciais
(Universidade Federal de Santa MariaBRAgronomiaUFSMPrograma de Pós-Graduação em Agronomia, 2016-02-29)
Rice is the main source of inorganic arsenic (Asi), a carcinogenic substance, in the human diet. In this sense, there is great interest in reducing the accumulation of As in rice grains. To achive this, field management / ...
Citogenotoxicidade, fenólicos totais e crescimento de Pfaffia glomerata (Spreng.) Pedersen cultivada sob concentrações de cobre e zinco
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em AgrobiologiaCentro de Ciências Naturais e Exatas, 2018-02-27)
Pfaffia glomerata (Spreng.) Pedersen, a native medicinal species, possesses the ability to accumulate metals, which can alter its production of metabolites and consequently their medicinal capacity. The objective of this ...
Efeito in vitro do polimorfismo ala16val do gene da superóxido dismutase dependente de manganês no metabolismo oxidativo de linfócitos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2010-03-05)
Epidemiological studies suggest that the imbalance in antioxidant enzymes activity genetically caused, increases the risk of metabolic disorders and chronic noncommunicable
diseases. This is the case of polymorphism that ...
Avaliação anatomopatológica de fígado, rim, pulmão e cérebro de camundongos expostos ao composto ditelureto de difenila
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2014-08-29)
Diphenyl ditelluride (PhTe)2 is an organic tellurium compound widely used as an intermediate in organic synthesis reactions and in the industry. Several studies have shown that this compound causes various toxic effects ...
Drogas anticâncer em efluente hospitalar: método, ocorrência, avaliação preliminar de risco, degradação por fotólise e ozonização
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2018-09-06)
In the last decade, the demand for anti-cancer drugs has grown considerably. These
products are one of the drug classes with great potential to cause harm to the
environment, even in low concentrations, and may have ...
Avaliação dos efeitos de compostos orgânicos de selênio e de telúrio sobre a integridade estrutural e funcional de células sangüíneas humanas
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2009-01-09)
In view of the need to expand the toxicologic studies of organochalcogens in biological systems, the aim of this study was to investigate the effect of exposure to
organic compounds of selenium (Se) and tellurium (Te) on ...