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Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation
(Facultad de Ciencias de la Salud, 2019)
Oxidative stress and mitochondrial dysfunction induced by metabolic insults are both hallmarks of various neurological disorders, whereby neuronal cells are severely affected by decreased glucose supply to the brain. Likely ...
Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction
(Springer/plenum PublishersNew YorkEUA, 2008)
Nitrate Induction of Primary Root Growth Requires Cytokinin Signaling in Arabidopsis thaliana
(2020)
Nitrate can act as a potent signal to control growth and development in plants. In this study, we show that nitrate is able to stimulate primary root growth via increased meristem activity and cytokinin signaling. Cytokinin ...
Crises paroxísticas recorrentes em ratos por inibição do transporte de glutamato durante o desenvolvimento
(Universidade Federal de São Paulo (UNIFESP), 2009-08-26)
It has been previously shown that cell-surface glutamate transporters efficiently control network activity in the maturing rodent brain, preventing the generation of seizures. In particular, inhibition of glutamate ...
Metabolic changes following perinatal Asphyxia: Role of astrocytes and their interaction with neurons
(Frontiers Research Foundation, 2016)
Efectos fisiológicos evidenciados a partir de cambios en hígado y riñón, asociados a la separación materna y al consumo de glutamato monosódico.
(Universidad Nacional de Colombia - Sede Bogotá, 2019-12-08)
Most mammals share in the early stages of life a bond given by the mother-child relationship. It has been demonstrated that the interruption of this bond given by maternal separation during lactation (SMDL) generates ...
Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: Implications for protection of striatal neurons expressing mutant huntingtin
(BioMed Central, 2020-10)
Background: Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary ...
Effects of guanethidine on electron transport and proton movements in rat heart, brain and liver mitochondria
(1985)
Guanethidine at 5-25 mM concentrations was found to induce up to 79% inhibition of ADP-stimulated (state III) oxygen consumption in isolated rat heart, brain or liver mitochondria, when the added substrate was glutamate ...
Modulação do sistema glutamatérgico em plaquetas: efeito de metais pesados e organocalcogênios
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2007-01-19)
Research strategies have been developed to characterize parameters in peripheral tissues that might easily be measured in humans as surrogate markers of damage, dysfunction or interactions involving neural targets of ...
Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion
(2014-04-18)
The subthalamic nucleus (STN) is a key area of the basal ganglia
circuitry regulating movement. We identified a subpopulation of
neurons within this structure that coexpresses Vglut2 and Pitx2,
and by conditional ...