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An HPLC-UV method for the quantification of zidovudine in rat plasma
(2013-11-01)
This work aims to develop and validate a simple methodology to quantify the most used antiretroviral, zidovudine (AZT), in rat plasma for preclinical studies. Some assays have been previously reported to quantify AZT in ...
Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets
(Wiley Blackwell Publishing, Inc, 2021-03)
Feed and drinking water are the most frequently used vehicles for administration of antibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. ...
Chitosan microparticles: influence of the gelation process on the release profile and oral bioavailability of albendazole, a class II compound
(Taylor & Francis, 2013-08)
Encapsulation of albendazole, a class II compound, into polymeric microparticles based on chitosan-sodium lauryl sulfate was investigated as a strategy to improve drug dissolution and oral bioavailability. The microparticles ...
The effect of smoking on the bioavailability of metronidazole in plasma and saliva
(Amer Dental AssocChicagoEUA, 2012)
A Nanostructures Lipid System to Improve the Oral Bioavailability of Ruthenium(II) Complexes for the Treatment of Infections Caused by Mycobacterium tuberculosis
(Frontiers Media Sa, 2018-12-06)
Tuberculosis (TB) is an infectious, airborne disease caused by the bacterium Mycobacterium tuberculosis that mainly affects the lungs. Fortunately, tuberculosis is a curable disease, and in recent years, death rates for ...
Improvement in the oral bioavailability and efficacy of new ezetimibe formulations—comparative study of a solid dispersion and different micellar systems
(MDPI, 2020)
Ezetimibe (EZ) is a poorly water-soluble drug with low bioavailability. Strategies such as solid dispersions (SD) and micellar systems (MS) were developed to identify the most effective drug delivery formulations with the ...
Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
(2011-04-01)
Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. ...
Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
(2011-04-01)
Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. ...
Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment
(2021-01-01)
Peptic ulcer disease (PUD) is a common condition that is induced by acid and pepsin causing lesions in the mucosa of the duodenum and stomach. The pathogenesis of PUD is a many-sided scenario, which involves an imbalance ...