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Synthesis, cytotoxicity and in vitro antileishmanial activity of naphthothiazoles
(2013-06-01)
The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp., which threatens millions of people worldwide. Current treatments exhibit high toxicity, and there is no vaccine available. The need for new ...
Fluorination methods in drug discovery
(Royal Society Of Chemistry, 2016-05)
Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence ...
Propolis: Is there a potential for the development of new drugs?
(Elsevier B.V., 2011-01-27)
Introduction: Propolis has plenty of biological and pharmacological properties and its mechanisms of action have been widely investigated in the last years, using different experimental models in vitro and in vivo. Researchers ...
Propolis: Is there a potential for the development of new drugs?
(Elsevier B.V., 2011-01-27)
Introduction: Propolis has plenty of biological and pharmacological properties and its mechanisms of action have been widely investigated in the last years, using different experimental models in vitro and in vivo. Researchers ...
TOPS-MODE based QSARs derived from heterogeneous series of compounds. Applications to the design of new anti-inflammatory compounds
(Pergamon-elsevier Science LtdOxfordInglaterra, 2004)
Early toxicity screening and selection of lead compounds for parasitic diseases
(Bentham Science Publishers Ltd, 2014)
Host pharmacokinetics and drug accumulation of anthelmintics within target helminth parasites of ruminants
(New Zealand Veterinary Assoc Inc, 2017-07)
Anthelmintic drugs require effective concentrations to be attained at the site of parasite location for a certain period to assure their efficacy. The processes of absorption, distribution, metabolism and excretion ...
Modern drug discovery technologies: opportunities and challenges in lead discovery
(Bentham ScienceBussum, 2011-12)
The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have ...
Old Drugs × New Perspectives/New Compounds × Old Necessities: Focusing on Combating Microbial Resistance – Part II
(Bentham Science Publishers, 2017)