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Synthesis, cytotoxicity and in vitro antileishmanial activity of naphthothiazoles
(2013-06-01)
The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp., which threatens millions of people worldwide. Current treatments exhibit high toxicity, and there is no vaccine available. The need for new ...
Filtering promiscuous compounds in early drug discovery: is it a good idea?
(ScienceDirect, 2016)
Computer-aided drug design against spike glycoprotein of SARS-CoV-2 to aid COVID-19 treatment
Background: SARS-CoV-2 has the Spike glycoprotein (S) which is crucial in attachment with host receptor and cell
entry leading to COVID-19 infection. The current study was conducted to explore drugs against Receptor ...
Nitroheterocyclic derivatives: privileged scaffold for drug development against Chagas disease
(2019-12-01)
Chagas disease or American trypanosomiasis is a major public health problem in Latin America. Approximately seven million people are currently infected worldwide. Despite the efforts to develop new drugs, only two ...
Micellar modification of drug stability: analysis of the effect of hexadecyltrimethylammonium halides on the rate of degradation of cephaclor
(1990-01-01)
The intra- and intermolecular rates of degradation of cephaclor were determined with and without hexadecyltrimethylammonium bromide (CTABr). Micellar-derived spectral shifts were used to measure the association of the ionic ...
Micellar modification of drug stability: analysis of the effect of hexadecyltrimethylammonium halides on the rate of degradation of cephaclor
(1990-01-01)
The intra- and intermolecular rates of degradation of cephaclor were determined with and without hexadecyltrimethylammonium bromide (CTABr). Micellar-derived spectral shifts were used to measure the association of the ionic ...
Analysis of extemporaneous oral liquid from commercially available drugs in hospital
(2016-07-01)
The objective of this study was to identify drugs that received dose adjustments (DA) and pharmaceutical alternatives (PA) that avoid DA, and calculate the economic percentage of this replacement. A descriptive, observational ...
Antiulcerogenic Compounds Isolated from Medicinal Plants
(2016-01-01)
The gastric mucosa is continuously exposed to damaging agents that are involved in the pathogenesis of gastric ulcers, the most common chronic gastrointestinal disease. Common habits such as stress, coffee ingestion, ...
Electrical Currents from Diffusion Equation and Electrodynamics at Targeted Drug Delivery Strategies
(Institute of Electrical and Electronics EngineersPE, 2021-10-22)
This paper presents a theoretical approach of a prospective scheme inside Nanomedicine known as Targeted Drug Delivery (TDD) based entirely on Classical Electrodynamics. Under the assumption that nanoparticles can be ...