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Chronic expression of wild-type Ret receptor in the mammary gland induces luminal tumors that are sensitive to Ret inhibition
(Nature Publishing Group, 2018-07)
The receptor tyrosine kinase Ret, a key gain-of-function mutated oncoprotein in thyroid carcinomas, has recently been implicated in other cancer types. While Ret copy number gains and mutations have been reported at low ...
Caracterização molecular e da sensibilidade a antimicrobianos de micobactérias de crescimento rápido (MCR) isoladas de pacientes submetidos a procedimentos invasivos do estado de Minas Gerais
(Universidade Federal de Minas GeraisUFMG, 2013-02-26)
Rapidly growing mycobacteria (RGM) are opportunistic pathogens involved mainly in infections associated with invasive procedures. Here, we have characterized RGM isolated from patients undergoing invasive procedures, from ...
Determinação dos padrões de Concentração Mínima Inibitória (MIC) e caracterização genotípica de cepas de Brachyspira hyodysenteriae isoladas de suínos com quadros clínicos de disenteria suína no Brasil
(Universidade Federal de Minas GeraisUFMG, 2014-01-23)
The objectives of this study were to characterize molecularly Brachyspira hyodysenteriae isolates obtained from pigs in Brazil and to evaluate their antimicrobial susceptibility profiles based on Minimal Inhibitory ...
Preparación y caracterización de un sustituto óseo inyectable de Hidroxiapatita/Biopolímero/Tetraciclina para ingeniería de tejidos del complejo maxilofacial
(2018)
El presente trabajo tiene como objetivo desarrollar un sustituto óseo inyectable compuesto de carragenano- hidroxipatita y doxiciclina, que es un tipo de tetraciclina, que sea adecuado para el uso en patologías del ...
Ehrlichia canis (Jaboticabal strain) induces the expression of TNF-alpha in leukocytes and splenocytes of experimentally infected dogs
(Colégio Brasileiro de Parasitologia Veterinária, 2011-03-01)
Canine ehrlichiosis is caused by the bacterium Ehrlichia canis and is characterized by a systemic febrile disease of unknown pathogenesis. This study evaluated the expression of cytokines TNF-alpha, IL-10, IFN-gamma, in ...
Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair
(2018-04-12)
Background: Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve ...
Endoglin regulates cyclooxygenase-2 expression and activity
(LIPPINCOTT WILLIAMS & WILKINS, 2006-08-04)
The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of ...
Imported scrub typhus: first case in South America and review of the literature
(2018)
Background
Scrub typhus is a neglected vector-borne zoonosis causing life-threatening illnesses, endemic in the Asian-Pacific region and, as recently discovered, in southern Chile. Scrub typhus is rarely reported in ...
Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells
(Springer Science+Business Media, 2014)
Divalent Metal Transporter 1 (DMT1) is
an apical Fe transporter in the duodenum and is
involved in endosomal Fe export. Four protein
isoforms have been described for DMT1, two from
mRNA with an iron responsive element ...