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Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes
(Wiley-Blackwell, 2014)
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage
(Wiley, 2009-12)
The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby ...
Screening methylation of DNA repair genes in the oral mucosa of chronic smokers
(2018-08-01)
Objective: The aim of this study was to evaluate the epigenetic changes in the process of oral carcinogenesis by screening the methylation of repair genes in chronic smokers. Design: Two groups were formed: Group 1: 16 ...
Landscape of mutations in DNA repair genes in young women with breast cancer
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-12-06)
There is a geographical difference in the distribution of breast cancer (BC) incidence for young women with BC (YWBC) under 40 years old (y.o.), with 15% in Latin America (LA) versus 7% in high-income countries. Most YWBC ...
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line
(2020-12-01)
Chronic inflammation resulting from Helicobacter pylori (H. pylori) infection, the major risk factor for gastric cancer, results in increased release of reactive oxygen species (ROS), promoting oxidative stress and DNA ...
Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the Trypanosoma cruzi TcI lineage: requirement of additional factors and detection of phosphorylation of the native form
(Springer, 2015)
Chagas disease, caused by the protozoan
Trypanosoma cruzi, is a major parasitic disease that affects
millions of people in America. However, despite the high
impact of this disease on human health, no effective and ...
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells
(ELSEVIER SCIENCE BV, 2008)
Ultraviolet (UV) light generates two major DNA lesions: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone photoproducts (6-4PPs), but the specific participation of these two lesions in the deleterious ...
Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs deficient context
(Springer, 2015-12)
Etoposide (ETO), a drug used for the treatment of human tumors, is associated with the development of secondary malignancies. Recently, therapeutic strategies have incorporated chemosensitizing agents to improve the tumoral ...
Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
(Elsevier Science, 2018-03)
Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks ...