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Electron migration in DNA matrix: an electron transfer reaction
(Editora Unesp, 1998-01-01)
Este artigo apresenta uma área de pesquisa atual, ativa e interessante. Descreve a investigação da química de transferência de elétrons (TE) de um modo geral e resultados de TE em DNA em particular. Dois intercalantes de ...
High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans
(BIOMED Central Ltd., 2017)
Background: Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12) ...
Temporal and spatial expression of genes involved in DNA methylation during reproductive development of sexual and apomictic Eragrostis curvula
(Nature Publishing Group, 2017-11-08)
Recent reports in model plant species have highlighted a role for DNA methylation pathways in the regulation of the somatic-to-reproductive transition in the ovule, suggesting that apomixis (asexual reproduction through ...
Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer
(Associação Brasileira de Divulgação Científica, 2008)
Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer death worldwide. DNA methylation is the most studied epigenetic alteration, occurring through a methyl radical addition to the ...
Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
(2017)
Background: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is ...
Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
(2017)
Background: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is ...
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
(Oxford University Press, 2014)
Genome-wide analysis of DNA methylation in human amnion
(HINDAWI publishing Corporation, 2013-02)
The amnion is a specialized tissue in contact with the amniotic fluid, which is in a constantly changing state. To investigate the importance of epigenetic events in this tissue in the physiology and pathophysiology of ...
Expression and methylation status of female-predominant GH-dependent liver genes are modified by neonatal androgenization in female mice
(Elsevier Ireland, 2013-11-13)
Neonatal androgenization masculinizes the GH axis and thus may impact on liver gene regulation. Neonatal testosterone administration to female mice decreased (defeminized) female predominant GH-dependent liver gene expression ...