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Could the Leukocyte X Chromosome Inactivation Pattern Be Extrapolated to Hair Bulbs?
(KARGER, 2010)
Background: The androgen receptor gene is located on the X chromosome with a polymorphic tract of CAG repeats that is inversely correlated to the receptor`s transactivation activity. A short CAG tract is associated with ...
The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight
(ELSEVIER SCIENCE SA, 2010)
Solar radiation sustains and affects all life forms on Earth. The increase in solar UV-radiation at environmental levels, due to depletion of the stratospheric ozone layer, highlights serious issues of social concern. This ...
Mechanistic insight of the photodynamic inactivation of Escherichia coli by a tetracationic zinc(II) phthalocyanine derivative
(Elsevier Science, 2009-03)
Photodynamic inactivation (PDI) of Escherichia coli has been studied in cultures treated with zinc(II) 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine (ZnPPc+4) to obtain insight about the mechanism of damage. ...
NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma
(Nature Publishing Group, 2017-12)
Chromatin modifying enzymes are frequently mutated in cancer, resulting in widespread epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic ...
Incorporation of 5-ethynyl-2'-deoxyuridine (EdU) as a novel strategy for identification of the skewed X inactivation pattern in balanced and unbalanced X-rearrangements
(Springer, 2016-02-01)
X-chromosome inactivation occurs randomly in normal female cells. However, the inactivation can be skewed in patients with alterations in X-chromosome. In balanced X-autosome translocations, normal X is preferentially ...
X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate
(Wiley-Blackwell, 2007-12-15)
Nonsyndromic clefts of the lip and/or palate are common birth defects with a strong genetic component. Based on unequal gender ratios for clefting phenotypes, evidence for linkage to the X chromosome and the occurrence of ...
Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.
(Public Library Science, 2013-11-21)
The maintenance of key germline derived DNA methylation patterns during preimplantation development depends on stores of DNA cytosine methyltransferase-1o (DNMT1o) provided by the oocyte. Dnmt1o(mat-/-) mouse embryos born ...
Inactivation of Streptococcus mutans genes lytST and dltAD impairs its pathogenicity in vivo
(2019-01-01)
Background: Streptococcus mutans orchestrates the development of a biofilm that causes dental caries in the presence of dietary sucrose, and, in the bloodstream, S. mutans can cause systemic infections. The development of ...
ERIC-PCR technique applied to monitoring and quantification of DNA damage during water disinfection process
(Elsevier Science Sa, 2019-11)
In this work, we propose a novel application of ERIC-PCR technique to study DNA damage after ultraviolet radiation (UV) and peracetic acid (PAA) treatment for water disinfection purpose. The efficacy of both treatments on ...
Cryptic mosaicism involving a second chromosome X in patients with Turner syndrome
(Associação Brasileira de Divulgação Científica, 2008)
The high abortion rate of 45,X embryos indicates that patients with Turner syndrome and 45,X karyotype could be mosaics, in at least one phase of embryo development or cellular lineage, due to the need for the other sex ...