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Multiple sites of tumorigenesis in transgenic mice overproducing hCG
(Elsevier Ireland, 2005-02)
We have produced transgenic (TG) mice expressing under the ubiquitin C promoter either the glycoprotein hormone common alpha-subunit (C(alpha)) or human chorionic gonadotropin (hCG) beta-subunit. C(alpha) overexpression ...
Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP
(Cell Press, 2015-09)
The glucocorticoid receptor (GR) is a steroid-hormone-activated transcription factor that modulates gene expression. Transcriptional regulation by the GR requires dynamic receptor binding to specific target sites located ...
Estudo fitoquímico e da atividade biológica de constituintes das raízes e galhos de Salacia crassifolia (Celastraceae)
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAPrograma de Pós-Graduação em QuímicaUFMG, 2019-11-27)
The phytochemical study of the roots and branches of Salacia crassifolia led to isolation of a betulin-betulinic acid mixture (SC19) and eighteen compounds: the sesquiterpene 9β, 10β-epoxy-3β-hydroxy-1βH,4βH,5βH,7βH,11αH ...
New lead compounds in the search for pure antiglucocorticoids and the dissociation of antiglucocorticoid effects
(Pergamon-Elsevier Science Ltd, 2009-02)
Antiglucocorticoids that act as antagonists at the glucocorticoid receptor (GR) level may be used to block or modulate the undesirable effects of glucocorticoid excess (from endogenous or exogenous origin). RU486 developed ...
Estudo fitoquímico e avaliação da atividade biológica de Tontelea Micrantha Mart. ex Schult. (Celastraceae)
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAPrograma de Pós-Graduação em QuímicaUFMG, 2019-08-09)
Phytochemical study and biological evaluation of Tontelea micrantha Mart. ex Schult. (Celastraceae)
The phytochemical study of leaves, branches and roots of Tontelea micrantha resulted in the isolation/identification ...
Família Celastraceae: caracterização química de óleos essenciais de nove espécies, compilado dos triterpenos pentacíclicos com foco nos dados de RMN de 13C, estudo fitoquímico das folhas de Pristimera celastroides e das folhas e raízes de Fraunhofera multiflora
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAPrograma de Pós-Graduação em QuímicaUFMG, 2022-05-20)
lants belonging to the Celastraceae family are considered as promising sources of bioactive compounds, especially pentacyclic triterpenes (TPs). This work aimed to carry out a bibliographic survey of pentacyclic triterpenes ...
Peptídeos antimicrobianos: síntese, ensaios biológicos, estudos termodinâmicos e análise estrutural por RMN em meios biomiméticos
(Universidade Federal de Minas GeraisUFMG, 2010-05-25)
Many organisms employ noxious chemicals (e.g., amines, steroid derivatives, alkaloids and peptides) to defend themselves against predators and pathogenic microrganisms. Among these chemical agents stand out peptides that ...