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Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis
(2008-07-01)
Coumarins represent an important class of phenolic compounds with multiple biological activities, including inhibition of lipidic peroxidation and neutrophil-dependent anion superoxide generation, anti-inflammatory and ...
Coumarins of haplopappus multifolius and derivative as inhibitors of lox: Evaluation in-vitro and docking studies
(Sociedad Chilena de Quimica, 2013)
Several natural compounds containing a coumarin moiety have been reported. They have multiple biological activities, e. g. , as scavengers of reactive oxygen species (ROS) and to reduce the inflammatory processes by ...
Seasonal variation in coumarin content of Mikania glomerata
(2000-12-12)
Mikania glomerata Spengal extract contains approximately 0.5 percent of coumarin, a substance that displays anti-inflammatory and expectoratory activities. Extracts from different young leaves of plants collected during ...
Seasonal variation in coumarin content of Mikania glomerata
(2000-12-12)
Mikania glomerata Spengal extract contains approximately 0.5 percent of coumarin, a substance that displays anti-inflammatory and expectoratory activities. Extracts from different young leaves of plants collected during ...
Synthesis and electrochemical oxidation of hybrid compounds: Dihydropyridine-fused coumarins
(2014)
In this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemically characterized in dimethylformamide (DMF). Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
Coumarin Derivatives in Inflammatory Bowel Disease
(2021-01-15)
Inflammatory bowel disease (IBD) is a non-communicable disease characterized by a chronic inflammatory process of the gut and categorized into Crohn's disease and ulcerative colitis, both currently without definitive ...
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)coumarin derivatives: Effect on inducible nitric oxide synthase
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERPARIS, 2012)
A series of 3-(triazolyl)-coumarins were synthesized and tested as anti-inflammatory agents. It was possible to infer that these compounds do not alter the interaction of LPS with TLR-4 or TLR-2, as the intracellular ...
Late-stage electron-catalyzed perfluoroalkylation of coumarin derivatives—Thermal fluoroalkyl radical production from sodium perfluoroalkyl sulfinate salts
(Elsevier Science Sa, 2017-05)
Novel and high-yielding protocols for the late-stage synthesis of 3-perfluoroalkyl-substituted coumarin derivatives employing either perfluoroalkyl iodides RFI or sodium perfluoroalkylsulfinate salts NaSO2RF as perfluoroalkyl ...
Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study
(2019-11-01)
Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known ...