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Pathological hypertrophy and cardiac dysfunction are linked to aberrant endogenous unsaturated fatty acid metabolism
(Public Library Science, 2018-03-01)
Pathological cardiac hypertrophy leads to derangements in lipid metabolism that may contribute to the development of cardiac dysfunction. Since previous studies, using high saturated fat diets, have yielded inconclusive ...
Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na+–HCO3− cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin–angiotensin system
(Oxford University Press, 2014-02)
Aims Electroneutral (NBCn1) and electrogenic (NBCe1) isoforms of the Na+–HCO3− cotransporter (NBC) coexist in the heart. We studied the expression and function of these isoforms in hearts of Wistar and spontaneously ...
Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy
(1993)
Objective: The aim was to clarify the role of cyclic AMP dependent protein kinase (PKA) and changes in mechanical heart function during development of cardiac hypertrophy induced by volume overload. Methods: Protein and ...
Participação do Estado Contrátil e do Relaxamento Miocárdico na Disfunção Ventricular durante a Transição Hipertrofia-Falência Cardíaca
(1997-12-01)
Purpose - To investigate the participation of contractile state and relaxation in cardiac muscle dysfunction during the transition from stable hypertrophy to cardiac decompensation in aging spontaneously hypertensive rats ...
Participação do Estado Contrátil e do Relaxamento Miocárdico na Disfunção Ventricular durante a Transição Hipertrofia-Falência Cardíaca
(1997-12-01)
Purpose - To investigate the participation of contractile state and relaxation in cardiac muscle dysfunction during the transition from stable hypertrophy to cardiac decompensation in aging spontaneously hypertensive rats ...
Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
(BioMed Research International, 2016-09-18)
Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells. However, the role of the jumonji family of demethylases in the development of cardiac ...
Cardiac Remodeling Induced by All-Trans Retinoic Acid is Detrimental in Normal Rats
(2017-11-01)
Background/Aims: This study aimed to discern whether the cardiac alterations caused by retinoic acid (RA) in normal adult rats are physiologic or pathologic. Methods and Results: Wistar rats were assigned into four groups: ...
Role of vitamin D in the cardiac remodeling induced by tobacco smoke exposure
(Elsevier B.V., 2012-03-22)
Role of vitamin D in the cardiac remodeling induced by tobacco smoke exposure
(Elsevier B.V., 2012-03-22)