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Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed
(Wiley Blackwell Publishing, Inc, 2005-10)
In the isolated rat mesenteric bed, the 1 min perfusion with 100 nM anandamide, a concentration that did not evoke vasorelaxation, elicited an acute release of 165.1 ± 9.2 pmol nitric oxide (NO) that was paralleled by a ...
Inhalation of marijuana affects drosophila heart function
(Company of Biologists Ltd, 2019-08)
We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time ...
Flakka use among high school seniors in the United States
(ELSEVIER IRELAND LTD, 2019)
Background: Use of synthetic cathinones, commonly referred to as"bath salts", has been associated with tens of thousands of emergency department visits in the US; however, few national studies have estimated prevalence of ...
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function
(2018)
The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1 beta/TNF-alpha) known to lead to vascular ...
Cannabidiol (Cbd) alters the functionality of neutrophils (pmn). implications in the refractory epilepsy treatment
(Molecular Diversity Preservation International, 2021-03)
Cannabidiol (CBD), a lipophilic cannabinoid compound without psychoactive effects, has emerged as adjuvant of anti‐epileptic drugs (AEDs) in the treatment of refractory epilepsy (RE), decreasing the severity and/or frequency ...
The role of cervical endocannabinoid system in the modulation of lipopolysaccharide-induced proinflammatory response
(Elsevier, 2019)
The endocannabinoid system (ECS) is one of the numerous signaling pathways that have been involved in the pathophysiology of pregnancy. The endogenous ligands of cannabinoid receptors (CB1 and CB2) are mainly anandamide ...
Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus
(Pergamon-Elsevier Science Ltd, 2013-09)
Objective: The aim of this study was to investigate the factors that could participate on salivary glands hypofunction during inflammation and the participation of endocannabinoids in hyposalivation induced by the presence ...
Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation
(Wiley-liss, Div John Wiley & Sons Inc, 2019-02)
Fibronectin (Fn) enhances human sperm capacitation via the cAMP/PKA pathway, and the endocannabinoid system participates in this process. Moreover, Fn has been linked to endocannabinoid system components in different ...
Anandamide-nanoformulation obtained by electrospraying for cardiovascular therapy
(Elsevier Science, 2019-07)
Anandamide (AEA), an endogenous cannabinoid, has a relevant antihypertensive effect. However, its cardioprotective role has been barely explored due to unfavorable physico-chemical properties and, sometimes, undesirable ...
Papel do receptor canabinóide CB2 e sua relação com a NNOS no reparo endotelial e remodelamento vascular
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2019-06-13)
Studies with cell, animal, and human models consistently demonstrate that current surgical and antiproliferative therapies delay, but do not prevent, hyperplasia of the media and intima arterial layers, regardless of ...