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An astroglia-linked dopamine D2-receptor action in prefrontal cortex
(National Academy of Sciences, 2001-02)
Typical neuroleptic drugs elicit their antipsychotic effects mainly by acting as antagonists at dopamine D2 receptors. Much of this activity is thought to occur in the cerebral cortex, where D2 receptors are found largely ...
Atp and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
(WILEY-BLACKWELL, 2011)
Inflammation contributes to neurodegeneration in post-ischemic brain, diabetes, and Alzheimer's disease. Participants in this inflammatory response include activation of microglia and astrocytes. We studied the role of ...
Assessment of neurotoxicity of monocrotaline, an alkaloid extracted from Crotalaria retusa in astrocyte/neuron co-culture system
(2011)
Studies have shown cases of poisoning with plants from the genus Crotalaria (Leguminosae) mainly in animals. They induce damages in the central nervous system (CNS), which has been attributed to toxic
effects of the ...
Immunohistochemical study of six cases of Taylor's type focal cortical dysplasia: Correlation with electroclinical data
(Blackwell Publishing Inc, 2002-01-01)
Purpose: Cortical specimens from six patients operated on for drug-resistant epilepsy diagnosed as Taylor's type focal cortical dysplasia were submitted to neuropathological and immunohistochemical studies.Methods: All ...
Endothelinergic cells in the subependymal region of mice
(Elsevier Science, 2010-03)
Endothelin (ET) is a small peptide that activates astrocyte proliferation, regulates proliferation and migration of embryonic neural precursor cells and stimulates glioblastoma growth. We found that in mouse brain, ET and ...
Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases
(2014-03)
The morphogen Sonic Hedgehog (SHH) plays a critical role in the development of
different tissues. In the central nervous system, SHH is well known to contribute to
the patterning of the spinal cord and separation of the ...
Roles of ZBTB20 in the specification of upper layer neurons and astrocytes in the neocortex
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS, 2019-12-17)
Organization of neocortical circuits is critical for sensory perception, learning and
multisensory integration. In the primary somatosensory area (S1) layer IV neurons
receive thalamic inputs and synapse onto layer II/III ...