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Voxel model in BNCT treatment planning: Performance analysis and improvements
(IOP Publishing, 2005-01)
In recent years, many efforts have been made to study the performance of treatment planning systems in deriving an accurate dosimetry of the complex radiation fields involved in boron neutron capture therapy (BNCT). The ...
In vitro studies of DNA damage and repair mechanisms induced by BNCT in a poorly differentiated thyroid carcinoma cell line
(Springer, 2018-05)
Boron neutron capture therapy (BNCT) for aggressive tumors is based on nuclear reaction [10B (n, α) 7Li]. Previously, we demonstrated that BNCT could be applied for the treatment of undifferentiated thyroid carcinoma. The ...
Diseño, síntesis y evaluación biológica de nuevos organoboranos con uso en terapia antitumoral de glioblastoma por captura neutrónica de boro (10B)
(Udelar. FQ, 2019)
En la presente tesis doctoral se pretende profundizar en las respuestas a preguntas de relevancia en un tema de salud humana como es la farmacología para el tratamiento de enfermedades neoplásicas, en particular, glioblastoma ...
Characterization and modeling of a MoTaVWZr high entropy alloy
(Elsevier Ltd, 2016-12)
As part of a project for developing Accelerator–Based Boron Neutron Capture Therapy (AB-BNCT), for which the generation of neutrons through nuclear reactions like 9Be(d,n) is necessary, a new material that preserves its ...
A "Trojan horse" strategy to reverse drug-resistance in brain tumors
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2014)
Malignant gliomas represent one of the most aggressive forms of Central Nervous System
(CNS) tumors. According to the WHO classification of brain tumors, astrocytomas have been
categorized into four grades, determined ...
Sunitinib-containing carborane pharmacophore with the ability to inhibit tyrosine kinases receptors FLT3, KIT and PDGFR-β, exhibits powerful in vivo anti-glioblastoma activity
(MDPI, 2020)
Malignant gliomas are the most common malignant and aggressive primary brain tumors in adults, the prognosis being—especially for glioblastomas—extremely poor. There are no effective treatments yet. However, tyrosine kinase ...
End-to-end range prediction for heavier ion radiation therapy based on Monte Carlo simulations
(Universidad Nacional de ColombiaBogotá - Ciencias - Maestría en Física MédicaDepartamento de FísicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2020)
The presence of range uncertainties in charged particle therapy with light ions (CPT) requires the employment of safety margins during treatment planning. These affect treatment quality, not allowing to fully exploit the ...