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Heterogeneous acid catalysts prepared by immobilization of H3PW12O40 on silica through impregnation and inclusion, applied to the synthesis of 3H-1,5-benzodiazepines
(Elsevier B.V., 2020-04)
Solid acid catalysts were successfully prepared using mesoporous silica (MESOSI) as support and tungstophosphoric acid (KTPA) as active phase, which was incorporated by impregnation (MESOSI#KTPA) and inclusion (MESOSI@KTPA). ...
GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons
(American Society for Biochemistry and Molecular Biology, 2005-06)
Changes in the function of type A γ-aminobutyric acid receptors (GABAARs) are associated with neuronal development and tolerance to the sedative-hypnotic effects of GABAAR positive modulators. Persistent activation of ...
Role of fluorine-fluorine and weak intermolecular interactions in the supramolecular network of a new trifluoromethyl-1,5-benzodiazepine: Crystal structure, Hirshfeld surface analysis and theoretical study
(Elsevier Science SA, 2021-02)
A new trifluoromethyl-1,5-benzodiazepine (BDZP) was synthesized from 2-trifluoromethyl chromone and ophenylendiamine in ethanol. The X-ray crystal structure determination of BDZP shows that the compound exists in the solid ...
Melatonin and Benzodiazepine/Z-Drug Abuse
(Springer, 2019)
A temporal relationship between the nocturnal rise in melatonin secretion and the increase in sleep propensity at the beginning of the night, coupled with the sleep-promoting effects of exogenous melatonin, supports the ...
Automedicación y riesgo de abuso con benzodiacepinas en pacientes adultos Lima-Perú, 2019
(Sociedad de Neurologia Psiquiatria y NeurocirugiaCL, 2021-09-26)
"Introduction: Benzodiazepines have the potential to generate abuse, so an indiscriminate consumption,
through the sale without prescription and the practice of self-medication, would mean a high risk due to
their abuse. ...
Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator
(National Academy of Sciences, 2005-05)
Benzodiazepines remain widely used for the treatment of anxiety disorders despite prominent, often limiting side effects including sedation, muscle relaxation, and ataxia. A compound producing a robust anxiolytic action ...
Similar anxiolytic-like effects following intra-amygdala infusions of benzodiazepine receptor agonist and antagonist: Evidence for the release of an endogenous benzodiazepine inverse agonist in mice exposed to elevated plus-maze test
(Elsevier B.V., 2009-04-24)
Previous studies have demonstrated that microinjections of midazolam, a benzodiazepine receptor agonist, into the amygdala produce anxiolytic-like effects in elevated plus-maze (EPM)-naive rodents. However, systemic or ...
Similar anxiolytic-like effects following intra-amygdala infusions of benzodiazepine receptor agonist and antagonist: Evidence for the release of an endogenous benzodiazepine inverse agonist in mice exposed to elevated plus-maze test
(Elsevier B.V., 2009-04-24)
Previous studies have demonstrated that microinjections of midazolam, a benzodiazepine receptor agonist, into the amygdala produce anxiolytic-like effects in elevated plus-maze (EPM)-naive rodents. However, systemic or ...