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A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
(Associação Paulista de Medicina - APM, 1995-02-01)
Dioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, ...
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
(Associação Brasileira de Divulgação Científica, 2011-10-01)
It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a ...
Trends in drug use among students in Brazil: analysis of four surveys in 1987, 1989, 1993 and 1997
(Associação Brasileira de Divulgação Científica, 2004-04-01)
The consumption of psychotropic drugs among Brazilian secondary school students was examined by comparing data from four surveys using a questionnaire adapted from the WHO's Program on Research and Reporting on the ...
Behavioral Profiles in Rats Distinguish Among "Ecstasy," Methamphetamine and 2,5-Dimethoxy-4-Iodoamphetamine: Mixed Effects for "Ecstasy" Analogues
(AMER PSYCHOLOGICAL ASSOC, 2010-06-30)
3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) is a psychoactive drug structurally related to
other phenylisopropylamines acting as stimulants or hallucinogens in humans. Although MDMA has a
pharmacological identity ...
Differential behavioral outcomes of 3,4-methylenedioxymethamphetamine (MDMA-ecstasy) in anxiety-like responses in mice
(Associação Brasileira de Divulgação Científica, 2011)
Anxiolytic and anxiogenic-like behavioral outcomes have been reported for methylenedioxymethamphetamine (MDMA or ecstasy) in rodents. In the present experiment, we attempted to identify behavioral, hormonal and neurochemical ...
The psychiatric side-effects of rimonabant
(Associação Brasileira de Psiquiatria - ABP, 2009)
OBJECTIVE: Experimental evidence has suggested that drugs that enhance cannabinoid type-1 (CB1) receptor activity may induce anxiolytic and antidepressant effects, whilst the opposite has been reported with antagonists. ...
The effects of diazepam on the elevated T-maze are dependent on the estrous cycle of rats
(Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, 2009)
In order to determine the modulation of anxiolytic and panicolytic-like effects of diazepam by the hormonal cycle of female rats, male and female rats - the latter divided per estrous cycle phase (estrus, diestrus, metaestrus ...
Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors
(LIPPINCOTT WILLIAMS & WILKINS, 2010)
Cannabidiol (CBD) is a major nonpsychotomimetic component of Cannabis sativa that has been shown to have an anxiolytic effect in human and animal models. Earlier studies suggest that these effects involve facilitation of ...
FACILITATION OF ENDOCANNABINOID EFFECTS IN THE VENTRAL HIPPOCAMPUS MODULATES ANXIETY-LIKE BEHAVIORS DEPENDING ON PREVIOUS STRESS EXPERIENCE
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Although several pieces of evidence indicate that the endocannabinoid system modulates anxiety-like behaviors and stress adaptation, few studies have investigated the brain sites of these effects. The ventral hippocampus ...
Facilitation of 5-HT(2A/2C)-mediated neurotransmission in the ventromedial hypothalamic nucleus decreases anxiety in the elevated T-maze
(ELSEVIER SCIENCE BV, 2011)
Previous evidence has shown that facilitation of GABA/benzodiazepine-mediated neurotransmission in the ventromedial hypothalamus (VMH) inhibits both escape and inhibitory avoidance responses generated in the elevated T-maze ...