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Vulnerability of calbindin, calretinin and parvalbumin in a transgenic/knock-in APPswe/PS1dE9 mouse model of Alzheimer disease together with disruption of hippocampal neurogenesis

Verdaguer E.; Brox S.; Petrov D.; Olloquequi J.; Romero R.; de Lemos M.L.; Camins A.; Auladell C. (Elsevier Inc., 2015)

Mice lacking M1 and M3 muscarinic acetylcholine receptors have impaired odor discrimination and learning

Chan W.; Singh S.; Keshav T.; Dewan R.; Eberly C.; Maurer R.; Nunez-Parra A.; Araneda R.C. (Frontiers Research Foundation, 2017)

Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy

Miyabara, Elen Haruka; Nascimento, Tábata Leal; Rodrigues, Debora C.; Moriscot, Anselmo Sigari; Davila, Wilmer F.; AitMou, Younss; deTombe, Pieter P.; Mestril, Ruben (SPRINGERNEW YORK, 2012)

Heat shock proteins play a key regulatory role in cellular defense. To investigate the role of the inducible 70-kDa heat shock protein (HSP70) in skeletal muscle atrophy and subsequent recovery, soleus (SOL) and extensor ...

Endogenous annexin-A1 negatively regulates mast cell-mediated allergic reactions

University of Malaya; Hammersmith Medicines Research; Universidade Estadual Paulista (Unesp); Queen Mary University of London (2019-01-01)

Mast cell stabilizers like cromoglycate and nedocromil are mainstream treatments for ocular allergy. Biochemical studies in vitro suggest that these drugs prevent mast cell degranulation through the release of Annexin-A1 ...

Altered reactivity of gastric fundus smooth muscle in the mouse with targeted disruption of the kinin B(1) receptor gene

BARBOSA, Ana M. R. B.; FELIPE, Sandra A.; ARAUJO, Ronaldo C.; KAWAMOTO, Elisa M.; CARVALHO, Maria H. C.; SCAVONE, Cristoforo; PESQUERO, Joao B.; SHIMUTA, Suma I. (ELSEVIER SCIENCE INC, 2009)

Relaxing action of sodium nitroprusside (SNP) was significantly reduced in the stomach fundus of mice lacking the kinin B(1) receptor (B(1)(-/-)). Increased basal cGMP accumulation was correlated with attenuated SNP induced ...

Mechanisms involved in the loss of brown adipose tissue in the AGPAT2 deficient mouse

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (2019)

1-acylglycerol-3-phosphate O-acyltransferase-2 (AGPAT2) is an enzyme that participates in the synthesis of triacylglycerols and glycerophospholipids. In the differentiation of adipocytes (adipogenesis) the storage of lipids ...

CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice

BEREZNIUK, Iryna; SIRONI, Juan; CALLAWAY, Myrasol B.; CASTRO, Leandro M.; HIRATA, Izaura Y.; FERRO, Emer S.; FRICKER, Lloyd D. (FEDERATION AMER SOC EXP BIOL, 2010)

Purkinje cell degeneration (pcd) mice have a mutation within the gene encoding cytosolic carboxypeptidase 1 (CCP1/Nna1), which has homology to metallocarboxypeptidases. To assess the function of CCP1/Nna1, quantitative ...

Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms

de Lemos L.; Junyent F.; Camins A.; Castro-Torres R.D.; Folch J.; Olloquequi J.; Beas-Zarate C.; Verdaguer E.; Auladell C. (Humana Press Inc., 2018)

Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer’s Disease

Ettcheto M.; Abad S.; Petrov D.; Pedrós I.; Busquets O.; Sánchez-López E.; Casadesús G.; Beas-Zarate C.; Carro E.; Auladell C.; Olloquequi J.; Pallàs M.; Folch J.; Camins A. (Humana Press Inc., 2018)

Cortical granule exocytosis is mediated by alpha-SNAP and N-Ethilmaleimide sensitive factor in mouse eggs

de Paola, Maria Matilde; Bello, Oscar Daniel; Michaut, Marcela Alejandra (Public Library of Science, 2015-08-12)

Cortical granule exocytosis (CGE), also known as cortical reaction, is a calciumregulated secretion that represents a membrane fusion process during meiotic cell division of eggs. The molecular mechanism of membrane fusion ...

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