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Dengue-3 Virus Entry into Vero Cells: Role of Clathrin-Mediated Endocytosis in the Outcome of Infection
(Public Library of Science, 2015-10)
The endocytic uptake and intracellular trafficking for penetration of DENV-3 strain H-87 into Vero cells was analyzed by using several biochemical inhibitors and dominant negative mutants of cellular proteins. The results ...
Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero and C6/36 cells
(Elsevier, 2014-02)
The aim of the present study was to analyze the influence of virus origin, mammalian or mosquito cell-derived, on antiviral susceptibility of DENV-2 to entry inhibitors and the association of this effect with any alteration ...
Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis
(Society for General Microbiology, 2008-02)
Entry of dengue virus 2 (DENV-2) into Aedes albopictus mosquito C6/36 cells was analysed using biochemical and molecular inhibitors, together with confocal and electron microscopy observations. Treatment with monodansylcadaverine, ...
Infectious dengue-1 virus entry into mosquito C6/36 cells
(Elsevier Science, 2011-09)
The entry of dengue virus-1 (DENV-1) strain Hawaii into mosquito C6/36 cells was analyzed using a variety of biochemical inhibitors together with electron microscopy. The treatment with ammonium chloride, chlorpromazine, ...
Blockade of dengue virus entry into myeloid cells by endocytic inhibitors in the presence or absence of antibodies
(Public Library of Science, 2018-08)
Background: Dengue is the most prevalent arthropod-borne viral human disease in tropical and subtropical regions, caused by four dengue virus (DENV) serotypes. In spite of the increasing global incidence, no specific ...
Prediction of Non-canonical Routes for SARS-CoV-2 Infection in Human Placenta Cells
(2021-11-08)
The SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The data available about COVID-19 during pregnancy have demonstrated placental infection; however, the mechanisms associated with intrauterine transmission ...
Alternative infectious entry pathways for dengue virus serotypes into mammalian cells
(Wiley Blackwell Publishing, Inc, 2009-10)
The entry of two dengue virus (DENV) serotypes into Vero cells was analysed using biochemical inhibitors, dominant negative mutants of cellular proteins involved in endocytic pathways, fluorescence microscopy and infectivity ...
Human transferrin receptor triggers an alternative Tacaribe virus internalization pathway
(Springer Wien, 2016-02)
Tacaribe virus (TCRV) entry occurs by receptor-mediated endocytosis. To explore the entry mechanism used by TCRV, the inhibitory effects of drugs and dominant negative (DN) constructions affecting the main endocytic pathways ...
Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
(Elsevier Inc, 2013-10)
The target cell tropism of enveloped viruses is regulated by interactions between viral proteins and cellular receptors determining susceptibility at a host cell, tissue or species level. However, a number of additional ...
A β-Hairpin motif in the envelope protein E2 mediates receptor binding of bovine viral diarrhea virus
(Multidisciplinary Digital Publishing Institute, 2021-06)
Pestivirus envelope protein E2 is crucial to virus infection and accomplishes virus-receptor interaction during entry. However, mapping of E2 residues mediating these interactions has remained unexplored. In this study, ...