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Ultra-long-acting antivirals as chemical vaccines to prevent viral diseases
For two centuries, vaccines have been successful in the fight against viruses, triggering immune protection. Indeed, the elimination of smallpox, the only infectious disease eradicated to date, was made possible through ...
Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection
(2022-07-01)
Monocytes play a major role in the initial innate immune response to SARS-CoV-2. Although viral load may correlate with several clinical outcomes in COVID-19, much less is known regarding their impact on innate immune ...
Real-Time PCR in HIV/Trypanosoma cruzi Coinfection with and without Chagas Disease Reactivation: Association with HIV Viral Load and CD4(+) Level
(PUBLIC LIBRARY SCIENCE, 2011)
Background: Reactivation of chronic Chagas disease, which occurs in approximately 20% of patients coinfected with HIV/Trypanosoma cruzi (T. cruzi), is commonly characterized by severe meningoencephalitis and myocarditis. ...
Aplicação da PCR em Tempo Real Para Detecção, Tipificaçãoe Carga Viral de Papilomavírus Bovino
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Genetica, 2017)
Ocular syndromes secondary to feline herpesvirus-1 infection-Review
(Univ Federal Rural Pernambuco, 2012-01-01)
The feline infectious respiratory disease is the most common diagnosed infection in the veterinary clinic routine, being the Feline Herpesvirus1 the most important causal agent. Once infected, the cat will become a lifetime ...
In vitro use of latency reversing agents to overcome HIV latency
(Universidade Federal de São Paulo (UNIFESP), 2017-02-23)
The use of antiretroviral therapy (ART) dramatically suppresses HIV replication to undetectable levels and can prolong the life of an infected individual, but low level viremia and proviral DNA are detected in majority of ...
Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus
(BioMed Central, 2019-05)
Background: The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma. During the chronic stage of BLV infection ...
Suppression of cancer growth by non-viral gene therapy based on a novel reactive oxygen species-responsive promoter
(Cell Press, 2009-08)
Increased reactive oxygen species (ROS) production has been reported as a distinctive feature of different pathologies including cancer. Therefore, we assessed whether increased ROS production in the cancer microenvironment ...
Participation of the nadph oxidase complex and p38 mapk in the production of cellular ros and in the sumoilation of the viral nucleoprotein, essential for the maturation and production of the viral progenie of isav
(2020)
Infectious salmon anemia virus (ISAv) is a pathogen capable of causing a serious clinical disease called infectious salmon anemia (ISA). Controlling this pathology poses a huge challenge for global and national salmon ...
Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus
(BioMed Central, 2019)
Background:
The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma. During the chronic stage of BLV ...