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Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice
(Frontiers Media Sa, 2017-10-04)
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures. For ...
Papel dos receptores vaniloides TRPV1 da matéria cinzenta periaquedutal na ansiedade e na antinocicepção induzida pelo medo em camundongos
(Universidade Federal de São CarlosBRUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF, 2013-05-03)
When confronted with fear situations rodents exhibit behavioral (e.g., fight, flight, immobility and vocalization) and neurovegetative (tachycardia, hypertension and defecation) responses that characterize the defense ...
Papel da Anandamida na modulação supraespinal da nocicepção e da antinocicepção induzida pelo estresse de derrota social
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2017-09-22)
Anandamide (AEA), initially considered an endocannabinoid, has recently been described as a vanilloid agonist capable of modulating acute pain in brain regions such as the periaqueductal gray (PAG). In this context, AEA ...
Determinants of anti-cancer effect of mitochondrial electron transport chain inhibitors: Bioenergetic profile and metabolic flexibility of cancer cells
(Bentham Science Publishers B.V., 2016)
© 2016 Bentham Science Publishers. Recent evidence highlights that energy requirements of cancer cells vary greatly from normal cells and they exhibit different metabolic phenotypes with variable participation of both ...
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms
(Pharmacological Research, 2006)
The anti-inflammatory pentacyclic triterpene, oleanolic acid (OA) was examined on acute nociception induced by intraplantar injection of capsaicin in mice. OA administered orally to mice at 10, 30 and 100 mg kg−1, significantly ...
Caracterización funcional del canal de potasio activado por calcio de conductancia intermedia (KCa3.1) en el endotelio de la córnea en condiciones fisiológicas y en ambientes hiperglúcidos
The cornea is the lens that protects the anterior surface of the eye and its transparent nature is a crucial part of the functioning of the eye. This characteristic is mainly determined by the activity of the cells of its ...