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Activation of melanocortin-4 receptor by a synthetic agonist inhibits ethanolinduced neuroinflammation in rats
(Bentham Science Publishers, 2019)
Morphologic changes and the expression of alpha-melanocyte stimulating hormone and melanocortin-1 receptor in melasma lesions: A comparative study
(2010-10-01)
Melasma is a common acquired symmetrical hypermelanosis characterized by irregular light- to dark-brown macules on sun-exposed skin areas. The literature shows few studies on its physiopathogeny. However, changes in ...
Morphologic changes and the expression of alpha-melanocyte stimulating hormone and melanocortin-1 receptor in melasma lesions: A comparative study
(2010-10-01)
Melasma is a common acquired symmetrical hypermelanosis characterized by irregular light- to dark-brown macules on sun-exposed skin areas. The literature shows few studies on its physiopathogeny. However, changes in ...
Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons
(Wiley Blackwell Publishing, Inc, 2014-06)
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in food intake and energy expenditure regulation. MC4R activation modifies neuronal activity but the molecular mechanisms by which this regulation ...
Clinical and biological phenotype of a patient with familial glucocorticoid deficiency type 2 caused by a mutation of melanocortin 2 receptor accessory protein
(BIOSCIENTIFICA LTD, 2007)
Familial glucocorticoid deficiency (FGD) is a rare inherited disorder which may be caused by mutations in the ACTH receptor (melanocortin 2 receptor, MC2R) named FGD type 1 or by mutations in the MC2R accessory protein ...
Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system
(2013)
Metabolic syndrome (MS) related to adult type 2
diabetes mellitus and cardiovascular disease is prevalent
among obese children/adolescents. Genetic variants of
the leptin-melanocortin system have been associated ...
Lorcaserin improves glycemic control via a melanocortin neurocircuit
(Elsevier Gmbh, 2017-10)
Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the ...
CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism. Within the hypothalamus, Kiss1 mRNA is expressed ...