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Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Calcium is an important second messenger in the rat pineal gland, as well as cAMP. They both contribute to melatonin synthesis mediated by the three main enzymes of the melatonin synthesis pathway: tryptophan hydroxylase, ...
Serotonin concentration, synthesis, cell origin, and targets in the rat caput epididymis during sexual maturation and variations associated with adult mating status: Morphological and biochemical studies
(Amer Soc Andrology, Inc, 2007-01-01)
The caput epididymis of some mammals contains large quantities of serotonin whose origin, targets, and physiological variations have been poorly studied. We combined morphological and biochemical techniques to begin ...
Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
The mammalian pineal gland synthesizes melatonin in a circadian manner, peaking during the dark phase. This synthesis is primarily regulated by sympathetic innervations via noradrenergic fibers, but is also modulated by ...
Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos
(JOHN WILEY & SONS, 2004-09-05)
Serotonin (5HT) plays major roles in the physiological regulation of many behavioral processes, including sleep, feeding, and mood, but the genetic mechanisms by which serotonergic neurons arise during development are ...
Associação de polimorfismos do gene da enzima Triptofano Hidroxilase 2 (TPH2) com a depressão
(Universidade Federal do PampaCampus São Gabriel, 2016)
Influência da mudança na dieta hiperlipídica para uma dieta padrão equilibrada sobre aspectos emocionais e cognitivos em camundongos obesos: estudo da neurotrofina BDNF (Brain Derived Neurotrophic Factor) e do sistema serotoninérgico
(Universidade Federal de São Paulo, 2021-10-28)
Introdução: As dietas obesogênicas, tais como as hiperlipídicas, são caracterizadas pela alta porcentagem de gorduras (principalmente as saturadas) no total de calorias ingeridas por porção e podem desencadear danos à saúde ...
The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal
(Public Library of Science, 2017)