The trisomy-16 (TS16) mouse is considered to be a model of human trisomy 21 (Down syndrome) because of genetic homology between mouse chromosome 16 and human chromosome 21. We examined cholinergic function of brain and ...

Evaluation of fetal well-being is a clinical challenge. The finding of absent or reverse diastolic flow (ADF/RDF) in the umbilical artery Doppler velocimetry is considered a sign of placental insufficiency. However, it is ...

We have established hippocampal cell lines from normal and trisomy 16 fetal mice, a model of human trisomy 21. Both cell lines, named H1b (derived from a normal animal) and HTk (trisomic) possess neuronal markers by ...

We have studied chorionic villi from 38 placentae obtained from spontaneous abortions at 7 to 12 weeks of pregnancy. Samples were separated into four groups: (1) early normal (7-9 weeks of pregnancy, normal karyotype); (2) ...

Down syndrome is determined by the presence of an extra copy of autosome 21 and is expressed by multiple abnormalities, with mental retardation being the most striking feature. The condition results in altered electrical ...

Supernumerary marker chromosomes (sSMC) may or may not be associated with an abnormal phenotype, depending on the presence of euchromatin, on their chromosomal origin and whether they are inherited. Over 80% of sSMCs are ...

The real mechanism involved in trisomies and leukemogenesis remains unknown and more information about this connection is essential, but unfortunately the clinical outcome and hematological profile of patients with isolated ...