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Trypanosomatidae diseases: from the current therapy to the efficacious role of trypanothione reductase in drug discovery
(Bentham Science Publishers, 2018)
Síntese de inibidores potenciais da tripanotiona redutase: base para o desenvolvimento de novos fármacos para tratamento da doença de Chagas e Leishmaniose
(Universidade Federal de Minas GeraisUFMG, 2012-02-28)
Trypanothione reductase (TR) is an enzyme found in trypanosomatids, which is involved in the reduction of trypanothione disulfide T[S]2 to the dithiol T[SH] and represents a key enzyme for the parasite antioxidant defense. ...
Análise das características estruturais do FAD em oxidorredutases
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Biotecnologia - PPGBiotecCâmpus São Carlos, 2015-08-11)
In this work, oxidoreductases of the glutathione reductase (GR), trypanothione reductase (TR) and sulfhydryl oxidase (SOX) sub-subclasses that are FAD (flavin adenine dinucleotide) dependent enzymes and contain a group ...