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Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states
(Elsevier Science, 2008-04)
Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of ...
Angular tricyclic benzofurans and related natural products of fungal origin. Isolation, biological activity and synthesis
(Royal Society of Chemistry, 2013-04)
Naturally-occurring angular tricyclic benzofuran derivatives of fungal origin and related compounds, in which two heterocyclic rings are fused to a central benzenoid moiety, are covered. Emphasis is placed on the structure ...
Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-To-head trials in acute major depression: Systematic review and meta-Analysis
(Sage Publications, 2017)
BACKGROUND:
A comparison across trials conducted over several decades suggested superior efficacy of tricyclic antidepressants (TCAs) over selective serotonin-reuptake inhibitors (SSRIs). However, this outcome may reflect ...
Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-To-head trials in acute major depression: Systematic review and meta-Analysis
(Sage Publications, 2017)
BACKGROUND:
A comparison across trials conducted over several decades suggested superior efficacy of tricyclic antidepressants (TCAs) over selective serotonin-reuptake inhibitors (SSRIs). However, this outcome may reflect ...
Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants
(Pergamon-Elsevier Science Ltd, 2003-12)
In addition to their well known actions on monoamine reuptake, tricyclic antidepressants have been shown to modulate ligand-gated ion channels (LGICs). Since the muscle nicotinic acetylcholine receptor (AChR) has been the ...
Análise das forças atuantes na estrutura de um chassi de triciclo tipo halfbike
(Universidade Tecnológica Federal do ParanáPato BrancoBrasilDepartamento Acadêmico de MecânicaEngenharia MecânicaUTFPR, 2016-06-22)
This monograph consists of the analysis of the forces acting on the chassis of a halfbike tricycle type, which presents itself as a new concept of vehicle for transport and entertainment. The halfbike consists in a tricycle ...
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
(2015-05-20)
Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ...
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
(2015-05-20)
Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ...
The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha(1B)-adrenoceptors
(Pergamon-Elsevier B.V. Ltd, 2010-07-01)
Although it is long known that the tricyclic antidepressants amitriptyline, nortriptyline and imipramine inhibit the noradrenaline transporter and alpha(1)-adrenoceptors with similar affinities, which may lead to self-cancelling ...