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Targeting stress pathways to treat neurological disorders linked to protein misfolding
(O'Doherty, C. B.Byrne, A. C. Nova Science, 2008)
Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Prion-related disorders (PrD) and Huntington's disease (HD) share a common neuropathology, primarily featuring ...
Is the Fas/Fas-L Pathway a Promising Target for Treating Inflammatory Heart Disease?
(Lippincott, Williams & Wilkins, 2009)
Treat to target in systemic lupus erythematosus: a commentary
(Springer, 2016)
Treat to target (T2T) strategies have proved to be useful in several chronic disorders, including Rheumatoid Arthritis. In systemic lupus erythematosus (SLE), T2T strategy has been proposed in order to control disease ...
Geographically targeted interventions versus mass drug administration to control Taenia solium cysticercosis, Peru
(Centers for Disease Control and Prevention, 2021)
Optimal control strategies for Taenia solium taeniasis and cysticercosis have not been determined. We conducted a 2-year cluster randomized trial in Peru by assigning 23 villages to 1 of 3 geographically targeted intervention ...
Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
(Frontiers Research Foundation, 2015-09)
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...
Network pharmacology and epilepsy
(Springer, 2016)
In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...
Targeting Endoplasmic Reticulum Stress Pathways to Treat Neurological Disorders Associated with Protein Misfolding
(Valenzuela, V.Bentham Science Publ., 2009)
Amyotrophic lateral sclerosis, Alzheimer’s Disease, Parkinson’s Disease, Prion-related Disorders, Huntington’s Disease and several other neurodegenerative disorders share a common neuropathology, primarily featuring the ...
Targeting stress pathways to treat neurological disorders linked to protein misfoldingProtein Misfolding
(O'Doherty, C. B.Byrne, A. C. Nova Science, 2020)
Multi-Output Tree Chaining: An Interpretative Modelling and Lightweight Multi-Target Approach
(2018-05-05)
Multi-target regression (MTR) regards predictive problems with multiple numerical targets. To solve this, machine learning techniques can model solutions treating each target as a separated problem based only on the input ...