Buscar
Mostrando ítems 1-10 de 196
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
(Pergamon-Elsevier Science Ltd, 2004-09)
We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent ...
Sterol methenyl transferase inhibitors alter the ultrastructure and function of the Leishmania amazonensis mitochondrion leading to potent growth inhibition
(Elsevier Gmbh, Urban & Fischer VerlagJenaAlemanha, 2007)
MOLECULAR DOCKING STUDY OF NATURALLYOCCURRING COMPOUNDS AS INHIBITORS OF N-MYRISTOYL TRANSFERASE TOWARDS ANTIFUNGAL AGENTS DISCOVERY
(Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Farmacia, 2015-05-01)
Fungal infections currently remain as a common problem in public health. Actually, drug discovery programs are oriented to the searching for lead structures. Virtual screening and molecular docking constitute great ...
8-Methoxypsoralen is a competitive inhibitor of glutathioneS-transferase P1-1
(Frontiers in Cellular Neuroscience, 2014-09-30)
Differential effects of flavonoids on bovine kidney low molecular mass protein tyrosine phosphatase
(Taylor & Francis LtdAbingdonInglaterra, 2006)
The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...
The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome-induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...