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Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma
(Elsevier, 2013-03)
Treatment of intraocular retinoblastoma with vitreous seeding is a challenge. Different routes of chemotherapy administration have been explored in order to attaining pharmacological concentrations into the posterior ...
Ocular topotecan pharmacokinetics following topical administration to rabbits for diffused anterior retinoblastoma
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2017-05)
Objectives: We characterized and compared the in-vivo absorption of topotecan into the aqueous humor after instillation of aqueous and ointment formulations. Methods: A lanolin/petrolatum ointment was used. New Zealand ...
Optimizing the storage of chemotherapeutics for ophthalmic oncology: Stability of topotecan solution for intravitreal injection
(Taylor & Francis, 2020-07)
Background: Intravitreal administration of topotecan shows activity against tumor vitreous seeding in the conservative treatment of retinoblastoma, a malignant tumor originated in the retina of small children. Adequate ...
Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery
(Public Library of Science, 2016-03)
Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic chemotherapy combined with radiation, but there is a clear need for ...
Clinical Pharmacokinetics of Intra-arterial Melphalan and Topotecan Combination in Patients with Retinoblastoma
(Elsevier, 2014-04)
Purpose: To assess the antitumor activity, toxicity, and plasma pharmacokinetics of the combination of
melphalan and topotecan for superselective ophthalmic artery infusion (SSOAI) treatment of children with
retinoblas ...
Ocular pharmacology of topotecan and its activity in retinoblastoma
(Lippincott Williams, 2014-09)
Purpose: To review the ocular pharmacology and antitumor activity of topotecan for the treatment of retinoblastoma by an evaluation of different routes of administration. Methods: Systematic review of studies available at ...
Sustained-release hydrogels of topotecan for retinoblastoma
(Elsevier Science, 2016-10)
Treatment of retinoblastoma, the most common primary ocular malignancy in children, has greatly improved over the last decade. Still, new devices for chemotherapy are needed to achieve better tumor control. The aim of this ...
Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma
(Wiley, 2013-05)
BACKGROUND: Treatment of eyes with retinoblastoma failing systemic chemoreduction and external beam radiotherapy is seldom efficacious. This study compares the efficacy and toxicity of intra-arterial ophthalmic artery ...