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Stereoselective analysis of thioridazine-2-sulfoxide and thioridazine-5-sulfoxide: An investigation of rac-thioridazine biotransformation by some endophytic fungi
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
The purpose of this study was to develop a method for the stereoselective analysis of thioridazine-2-sulfoxide (THD-2-SO) and thioridazine-5-sulfoxide (THD-5-SO) in culture medium and to study the biotransformation of ...
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis
(2017-01-01)
The neuroleptic drug thioridazine has been recently repositioned as possible anti-tubercular drug. Thioridazine showed anti-tubercular activity against drug resistant mycobacteria but it is endowed with adverse side effects. ...
Assignment of the absolute configuration at the sulfur atom of thioridazine metabolites by the analysis of their chiroptical properties: The case of thioridazine 2-sulfoxide
(ELSEVIER SCIENCE BV, 2010)
Thioridazine (THD) is a commonly prescribed phenotiazine neuroleptic drug, which is extensively biotransformed in the organism producing as main metabolites sulfoxides and a sulfone by sulfur oxidation Significant differences ...
Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface
(Elsevier Science, 2006-02-01)
In this work the interaction of Hydroxyzine, Promethazine and Thioridazine with Langmuir films of dipalmitoylphosphatidylcholine (dpPC) and dipalmitoylphosphatidic acid (dpPA), is studied. Temporal variations in lateral ...
In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine
(Elsevier, 2020-10-15)
Crotamine is a cationic polypeptide composed by 42 amino acid residues with several pharmacological and biological properties, including the selective ability to enter and kill actively proliferating tumour cells, which ...
Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface
(Elsevier Science BvAmsterdamHolanda, 2006)
Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease
(Elsevier Science, 2015-05)
Thioridazine (TDZ) is a phenothiazine that has been shown to be one of the most potent phenothiazines to inhibit trypanothione reductase irreversibly. Trypanothione reductase is an essential enzyme for the survival of ...