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Mostrando ítems 1-10 de 29
Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning
(Bentham Science Publishers, 2019)
Electrochemical characterization of tacrine, an antialzheimer's disease drug, and its determination in pharmaceuticals
(2000)
Tacrine, 9-amino-1,2,3,4-tetrahydroacridine, an antialzheimer's disease agent was electrochemically studied and a polarographic method for its quantitative determination in pharmaceuticals was developed. Tacrine was ...
Síntese, avaliação farmacológica e estudos computacionais de dímeros de tacrina
(Universidade Federal de Minas GeraisUFMG, 2014-03-14)
This work presents the synthesis of fifteen new tacrine dimers and results for Ki, IC50, kinetic mechanism and molecular docking analysis in relation to cholinesterases; and the assessment results of the antitumorigenic ...
Tacrina análogos: síntese, derivatização, bioatividade e fotofísica de sistemas heterocíclicos híbridos
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2023-01-27)
This thesis presents the results related to the synthesis, structural characterization and evaluation of the in vitro enzymatic inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of novel series of ...
Síntese e avaliação farmacológica de 7-amino-espiro[cromeno[4,3-b]quinolina-6,1’-cicloalcanos] e derivados
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2017)
The present thesis describes the synthesis and pharmacological evaluation of new tacrine structural analogues, as well as N-derivation reactions and C-C and C-N coupling on these compounds. By this way, a series of ...